Anatomy and regulation of the central melanocortin system

By Roger Cone. Nature Neuroscience, 2005

1,571 citations recorded by the source corpus.

Subfields: Cell Biology, Endocrine and Autonomic Systems, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/cc445ba3fd9c5cdc017e9e2ed4fd6f148a53bae5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Gareth Leng
2. K. Murphy
3. Jerrold M. Olefsky
4. M. Ludwig
5. C. de Luca
6. Stephen R. Bloom
7. A. N. van den Pol

In Endocrine and Autonomic Systems

1. A. N. van den Pol
2. Bradford B. Lowell
3. Gareth Leng
4. K. Murphy
5. Jerrold M. Olefsky
6. M. Ludwig
7. C. de Luca
8. Stephen R. Bloom

In Nutrition and Dietetics

1. Bradford B. Lowell
2. Gareth Leng
3. K. Murphy
4. Jerrold M. Olefsky
5. M. Ludwig
6. C. de Luca
7. Stephen R. Bloom
8. A. N. van den Pol

Citations in the corpus

• Gut hormones and the regulation of energy homeostasis (2006, background): “There are extensive reciprocal connections between the hypothalamus and the brainstem, and energy intake is coordinated on the basis of information received by both region”
• Dendritic peptide release and peptide-dependent behaviours (2006, background): “For example, AGRP has no direct effects on membrane excitability, but is an antagonist at the MC4 receptor, through which α-MSH act”
• Divergence of melanocortin pathways in the control of food intake and energy expenditure. (2005, background): “On the other hand, separate and different α-MSH and AgRP neuronal projections to other MC4R-containing areas must be important for melanocortin-mediated regulation of energy expenditure. regulation of energy homeostasis (Cone, 2005).”
• The Hormonal Control of Food Intake (2007, neutral): “, Cone, R.D., Jones, K.R., Tecott, L.H., and Reichardt, L.F. (2003). Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.”
• Semaglutide lowers body weight in rodents via distributed neural pathways. (2020, background): “POMC neurons also project to the PB (99, 100).”
• Neuropeptide transmission in brain circuits (2012, background): “AgRP is thought to act in a less direct inhibitory manner, by blocking the excitatory actions of POMC derived α-MSH on the MC4 melanocortin receptors (Cone,2005), although actions of AgRP independent of the MC4 receptor have also been described (Marsh et al,1999; Fu and van den Pol,2008).”
• Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. (2006, neutral): “Establishing the Functional Neuroanatomy of Body-Weight Control In recent years, a number of proteins have been identified, such as leptin, the leptin receptor (LEPR), and the melancortin-4 receptor, that play key roles in the central regulation of energy homeostasis (Ahima et al., 2000; Cone, 2005”
• Inflammation and insulin resistance (2008, background): “tion of gene expression, modification of enzymatic activity and regulation of energy homeostasis via actions in the arcuate nucleus (reviewed in [3,4]).”