Deletion of Ghrelin Impairs neither Growth nor Appetite

By Yuxiang Sun, Saira Ahmed, Roy G. Smith. Molecular and Cellular Biology, 2003

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The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review (2007, background): “Ghrelin does not seem to be a direct regulator of leptin, as fasting produces identical decreases in serum leptin in ghrelin null and wild-type mice (112).”
Ghrelin: structure and function. (2005, methodology): “A ghrelin knockout mouse was produced, and its phenotype was examined (227, 263, 264).”
The Hormonal Control of Food Intake (2007, neutral): “Given this, the first reports of mice with targeted deletions of ghrelin exhibiting no changes in feeding behavior or body composition were somewhat surprising (Sun et al., 2003; Wortley et al., 2004).”
Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. (2004, background): “Ghrelin has now been recognized to have pleiotropic functions in a variety of organ systems; however, studies by Smith and colleagues (43) have dem-”