An extensive network of coupling among gene expression machines

By T. Maniatis, R. Reed. Nature, 2002

1,207 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f8134fc93aab0ae623e29be9a0605471246bb19b

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In Molecular Biology

Citations in the corpus

A slow RNA polymerase II affects alternative splicing in vivo. (2003, background): “…are tightly coupledand Alberto R. Kornblihtt1,* 1Laboratorio de Fisiologı́a y Biologı́a Molecular to RNA polymerase II (pol II) transcription (for reviews see Maniatis and Reed, 2002; Bentley, 2002; ProudfootDepartamento de Fisiologı́a, Biologı́a Molecular y Celular et al., 2002; Neugebauer, 2002).”
Introns in gene evolution. (2003, background): “A model of how splicing is coupled with mRNA export nonsense-mediated decay has been excellently described by Reed and Magni (2001) and Maniatis and Reed (2002) .”
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (2007, background): “A current view of mRNA biogenesis incorporates multiple events simultaneously, including transcript elongation, CAP addition, pre-mRNA splicing, and polyadenylation, in addition to mRNA surveillance and export (Hirose and Manley, 2000; Maniatis and Reed, 2002; Orphanides and Reinberg, 2002; Proudfoo”
DEAD-box proteins: the driving forces behind RNA metabolism (2004, background): “However, the new emerging concept of interlinkage of different processes through common component”
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. (2003, background): “…et al., 2001) that is linked to subsequent events of mRNA production including capping, splicing,*Correspondence: kevin@hms.harvard.edu 4 These authors contributed equally to this work. polyadenylation, and nuclear export (Bentley, 2002; Ma- niatis and Reed, 2002; Orphanides and Reinberg, 2002).”
Function of alternative splicing. (2005, neutral): “, to the U1 and U2snRNP, which defines the 5V splice site and branch-point, respectively (Maniatis and Reed, 2002; Maniatis and Tasic, 2002).”
From silencing to gene expression: real-time analysis in single cells. (2004, background): “ger ribonucleoprotein particle (mRNP) export and translation (reviewed, Maniatis and Reed, 2002; Orphanides and Reinberg, 2002).”
Epigenetics in alternative pre-mRNA splicing (2011, neutral): “…might not apply to other RNA-processing events like capping and cleavage/polyadenylation (McCracken et al., 1997a, 1997b; Hirose and Manley, 1998; Maniatis and Reed, 2002; Moore and Proudfoot, 2009), wherein both the recruitment of the factors and enzymes involved as well as the catalysis appear…”
Integrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability (2011, background): “Regulation of gene expression is a coordinated multi-layered process involving many trans-acting factors (Maniatis and Reed, 2002; Keene, 2001).”
Analysis of Genes and Genomes (2004, background): “Indeed, recent evidence suggests the enzymes and cellular machinery involved in transcription, RNA processing and translation may be extensively coupled to form ‘gene expression factories’ that maximize the efficiency and specificity of each stage of gene expression (Maniatis and Reed, 2002).”
Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. (2005, background): “Observations to date indicate that the spliceosome operates within nuclear boundaries (Maniatis and Reed, 2002); a functional role for this complex in extranuclear domains has not been described.”
Transformation and microinjection (2006, background): “In addition, introns are important because pre-mRNA splicing promotes nuclear export, translation, and stability of mRNAs (Maniatis and Reed, 2002; Nott et al., 2004).”
Understanding alternative splicing: towards a cellular code (2005, background): “The C-terminal domain of the RNA pol II large subunit helps to recruit RNA processing factors to the emerging transcrip”
Genomic variants in exons and introns: identifying the splicing spoilers (2004, background): “In human cells, transcription and splicing are coordinately regulated in the nucleus in both a temporal and a spatial fashio”