From silencing to gene expression: real-time analysis in single cells.

By S. Janicki, T. Tsukamoto, S. Salghetti, W. Tansey, Ravi Sachidanandam, K. Prasanth, Thomas Ried, Y. Shav-Tal, E. Bertrand, R. Singer and 1 more. Cell, 2004

756 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cf041adb48fc56f98699e99d821df94a7d0d1d74

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In Molecular Biology

1. Richard A. Young
2. Tong Ihn Lee
3. Arjun Raj
4. B. Abraham
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Citations in the corpus

• Correlation of mRNA and protein in complex biological samples (2009, neutral): “The MS2-based technology can be embedded in a system that allow all the components involved in gene expression (DNA, RNA, protein) to be visualized in real time [13].”
• SINGLE-PARTICLE TRACKING (2009, methodology): “In the experiment [144,145], the gene was turned on, and the chromatin for that gene changed from condensed to expanded form.”
• Stochastic mRNA Synthesis in Mammalian Cells (2006, methodology): “Their study used the MS2 method of mRNA detection, which has previously been used to monitor real-time kinetics of gene activity [26].”
• A decade of 3C technologies: insights into nuclear organization. (2012, methodology): “Live-cell imaging methods that can track a single locus must be employed (Robinett et al. 1996; Janicki et al. 2004), possibly in combination with single-molecule detection methods, in order to provide further insight into the dynamics of the nuclear structure (Dange et al.”
• Regulating gene expression through RNA nuclear retention. (2005, background): “Recently, several studies using computational as well s experimental approaches have shown that more han w1700 new candidate human RNAs are potentially -to-I edited (Athanasiadis et al., 2004; Kim et al., 2004; evanon et al., 2004; Morse et al., 2002).”
• Transcription factors activate genes through the phase separation capacity of their activation domains (2018, methodology): “To investigate whether the aromatic mutant of GCN4 AD is impaired in its ability to recruit Mediator in vivo, the GCN4 AD and the GCN4 mutant AD were tethered to a Lac array in U2OS cells (Figure 7E) (Janicki et al., 2004).”
• Distinct factors control histone variant H3.3 localization at specific genomic regions (2010, background): “3 deposition in actively transcribed gene bodies may be coupled to transcription, potentially mediated by factors associated with elongating polymerase (Daury et al., 2006; Janicki et al., 2004; Schwartz and Ahmad, 2005).”
• Estrogen-receptor-α exchange and chromatin dynamics are ligand- and domain-dependent (2006, background): “Also, a combined lac operator and tet operator array system regulated by tetOn also demonstrated histone modifications in cis (Janicki et al., 2004; Tsukamoto et al., 2000).”
• An ATM-Dependent Transcriptional Silencing Program is Transmitted Through Chromatin in Cis to DNA Double Strand Breaks (2010, methodology): “This was achieved by modifying a previously described transcriptional reporter system (Janicki et al., 2004) with the capacity to create DSBs approximately 4–13 kb upstream of the promoter (Figure 1A).”