Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction

By N. Ishii, K. Ozaki, Hiroshi Sato, H. Mizuno, S. Saito, A. Takahashi, Y. Miyamoto, S. Ikegawa, N. Kamatani, M. Hori and 3 more. Journal of Human Genetics, 2006

637 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f793952f8718d9ceaee2cb99ff8c8aaaa52d6540

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Citations in the corpus

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression (2012, positive): “…lncRNAs such as GAS5 (Kino et al. 2010), LINC00568 (also known as ncRNA-a1), CYP4A22-AS1 (also known as ncRNA-a3) (Ørom et al. 2010), MIAT (Ishii et al. 2006), and MEG3 (Zhou et al. 2007) were nuclear enriched in at least two different cell types, consistent with their reported roles in…”
lincRNAs: Genomics, Evolution, and Mechanisms (2013, positive): “Miat sequence variants are also associated with increased risk of myocardial infarction (Ishii et al., 2006).”
The Genetic Signatures of Noncoding RNAs (2009, neutral): “infarction [188].”
Non‐coding RNAs: regulators of disease (2010, background): “It is not surprising, then, that the dysregulation of lncRNAs appears to be a primary feature of many complex human diseases, including leukaemia [175], colon cancer [176], prostate cancer [177], breast cancer [178], hepatocellular carcinoma [175,179], psoriasis [180], ischaemic heart disease [181,1”
Genome-wide computational identification and manual annotation of human long noncoding RNA genes. (2010, background): “In particular, functional analysis of lncRNA genes residing in disease candidate regions (Schaefer et al. 2009) or in linkage disequilibrium with disease-associated SNPs (Ishii et al. 2006) should reveal entry points for investigating the phenotypic impact of the long non-coding transcriptome.”
lncRNAdb: a reference database for long noncoding RNAs (2010, background): “It also aims to decrease instances of replication and unknown identity by the inclusion of aliases such as p15AS , which was reported as a novel antisense RNA (24), but appears to be an unspliced isoform of a previously described ncRNA called ANRIL (25), and Gomafu (26), which is also known as MIAT ”
Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “Similarly in heart disease, SNPs mapped to a number of lncRNAs including myocardial infarction associated transcript (MIAT) [109], antisense non-coding RNA in the INK4 locus (ANRIL) [110], and the aforementioned H19 [111] have been shown to have a disease association.”
Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs (2013, background): “Furthermore, lincRNAs were found to be strongly enriched for intergenic TASs compared to nonexpressed intergenic regions (Figure 4).”
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs (2012, background): “Aside from their roles in cancer, lncRNAs are known to be dysregulated in several other diseases, including heart disease (92,93), Alzheimer’s disease (94), psoriasis (95), spinocerebellar ataxia type 8 (96) and fragile X syndrome (97).”
Braveheart, a long non-coding RNA required for cardiovascular lineage commitment (2013, background): “In addition, human MIAT was identified as a novel long non-coding RNA associated with increased risk of myocardial infarction (Ishii et al., 2006).”