lincRNAs: Genomics, Evolution, and Mechanisms

By Igor Ulitsky, David P. Bartel. Cell, 2013

2,507 citations recorded by the source corpus.

Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gene regulation and other cellular processes. This Review outlines the emerging understanding of lincRNAs in vertebrate animals, with emphases on how they are being identified and current conclusions and questions regarding their genomics, evolution and mechanisms of action.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/adc6bf664b55d3f79bafb4d3cce4b06ff8c4000a

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Citations in the corpus

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons (2013, background): “…between genes and proteins has undergone a revolution in recent years with discoveries of both new classes of RNAs (e.g., noncoding RNAs, (see Ulitsky and Bartel, 2013 for review) and new RNA-based mechanisms of gene regulation (e.g., microRNA and RNAi silencing) (see McNeill and Van Vactor,…”
Non-coding RNA: what is functional and what is junk? (2015, positive): “Since then, the number of new and putative functional ncRNAs has greatly expanded (for reviews see Wilusz et al., 2009; Wang and Chang, 2011; Ulitsky and Bartel, 2013; Rinn and Guttman, 2014).”
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution (2015, background): “When measured in bulk cell populations, lncRNAs are typically expressed at low levels compared to mRNAs [4,9].”
A census of human RNA-binding proteins (2014, background): “Nuclear lncRNAs play an active role in gene regulation by directing proteins to specific gene loci, where they recruit chromatin modification complexes and induce transcriptional silencing/activation (Ulitsky and Bartel, 2013).”
CRISPRi-based genome-scale identification of functional long non-coding RNA loci in human cells (2016, positive): “LncRNAs appear to have originated much later than protein coding genes, consistent with their not playing generic housekeeping roles (3, 56).”
LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse (2018, background): “In comparison, a large portion of the transcripts are non-coding RNAs (ncRNAs) (4), such as long ncRNAs (lncRNAs) lncRNA plays a crucial role in biological processes (5,6) and even in diseases (7–13).”
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “Additionally, while there are long intergenic RNAs (lincRNAs) [39] including eRNAs from gene-distal enhancers [40], the majority of lncRNA genes are located within 10 kb of protein-coding genes [41] and many lncRNAs are antisense to coding genes or intronic [42].”