The inhibitory cytokine IL-35 contributes to regulatory T-cell function
By L. Collison, C. Workman, Timothy T. Kuo, K. Boyd, Yao Wang, Kate M. Vignali, R. Cross, D. Sehy, R. Blumberg, D. Vignali. 2007
2,114 citations recorded by the source corpus.
Subfields: Immunology
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In Immunology
- Shimon Sakaguchi
- Alexander Y. Rudensky
- Arlene H. Sharpe
- J. Bluestone
- E. Shevach
- G. Freeman
- E. Wherry
- V. Kuchroo
Citations in the corpus
- The Foxp3+ regulatory T cell: a jack of all trades, master of regulation (2008, background): “IL-35, a heterodimeric protein composed of the IL-12 p35 chain and Ebi3, is regulated in T reg cells by Foxp3 (ref”
- Regulatory T cells and immune tolerance. (2008, background): “A recent study has shown that Foxp3 + natural Tregs predominantly produce immunosuppressive IL-35, a new member of the IL-12 family (Collison et al., 2007).”
- Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “Early studies suggested a functional anti-colitic role as Foxp3 Treg cells deficient in IL-35 production fail to suppress colitis in a T cell transfer model (Collison et al., 2007).”
- The gut microbiome shapes intestinal immune responses during health and disease (2009, positive): “Indeed, T Reg cells that are deficient in either of the two subunits of IL-35 (Epstein–Barr virus-induced protein 3 and IL-12α) cannot provide protection from induction of experimental coliti”
- Regulatory T cells: how do they suppress immune responses? (2009, background): “produce immunosuppressive IL-35, a novel member of the IL-12 family; IL-35-deficient Tregs are less suppressive in controlling IBD in vivo and in the suppression assay in vitro ( 35 ).”
- Mechanisms of foxp3+ T regulatory cell-mediated suppression. (2009, background): “One such candidate is IL-35, a new inhibitory cytokine, which may contribute substantially to the function of Treg cells by directly acting on responder T cells (Collison et al., 2007).”
- A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “More recently, a new type of iTreg, called iTR35, has been identified which mainly produces the suppressive cytokine IL-35, not IL-10 or TGF-β [188, 189].”