The G protein-coupled receptor repertoires of human and mouse

By D. Vassilatis, J. Hohmann, Hongkui Zeng, Fusheng Li, J. Ranchalis, M. Mortrud, Analisa Brown, Stephanie Rodriguez, J. Weller, A. Wright and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2003

801 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/f6dd9c52779bfbbf6ff4cabdbc2b2662c1de04c5

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Citations in the corpus

Ligand Discovery from a Dopamine D3 Receptor Homology Model and Crystal Structure (2011, background): “Prior to the release of the crystal coordinates, 26 top ranking compounds (2-27), all among the top 0.”
The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes (2005, background): “cently been described in detail (Joost and Methner 2002; Fredriksson et al., 2003c; Vassilatis et al., 2003), although there are still additional new human GPCRs being annotated (Fredriksson et al.”
Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. (2006, methodology): “In another study that included both the human and the mouse GPCRs, a high number of nonsensory GPCRs were collected through TBLASTN and HMM model searches [8].”
The Chemokine Superfamily Revisited (2012, positive): “Their receptors were soon identified and were found to be a subgroup of class A G protein-coupled receptors (GPCRs) (Vassilatis et al., 2003).”
Anatomical profiling of G protein-coupled receptor expression (2008, positive): “Although in vivo roles have been defined for many of the approximately 370 nonodorant GPCRs in mice and humans, the expression and function of many such receptors are incompletely characterized, and a significant fraction remain orphans (Fredriksson et al., 2003; Fredriksson and Schioth, 2005; Hill ”
PRESTO-TANGO: an open-source resource for interrogation of the druggable human GPCR-ome (2015, positive): “Approximately one-third of the nonolfactory GPCRs in the human genome are orphan GPCRs, whose endogenous or natural ligands are unknown 2–4 , whereas many more have been inadequately interrogated with respect to their ligands.”
Desensitization of G protein-coupled receptors and neuronal functions. (2004, background): “Of these nonsensory GPCRs, over 90% are expressed in the brain (Vassilatis et al. 2003).”
Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster (2006, positive): “7) demonstrates a similar distribution of GPR50 in the ependymal wall when compared with the hamster, albeit with a more sparse distribution than in situ hybridization data from hamster, mouse and rat (Drew et al. 2001, Vassilatis et al. 2003).”
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy (2006, background): “, 2003), of which 367 would be receptors for endogenous ligands, the remaining ones being olfactory and other chemosensory receptors (Vassilatis et al., 2003).”
The yak genome and adaptation to life at high altitude (2012, background): “…regard to sensory perception receptors (olfactory and taste) and other G protein–coupled receptor (GPCR) rhodopsin-like receptors, known to be involved in sensing of the extracellular environment 21 , we found significantly more GPCR transmembrane domains in yak than in cattle (1,558 versus 1,358).”