Desensitization of G protein-coupled receptors and neuronal functions.

By R. Gainetdinov, R. Premont, L. Bohn, R. J. Lefkowitz, M. Caron. Annual Review of Neuroscience, 2004

889 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/47f695a7154b6e95000f069208782923952a493e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. S. Rajagopal
2. R. Gainetdinov
3. J. Beaulieu
4. K. Rajagopal
5. R. Hen
6. Heidi E. Hamm
7. R. J. Lefkowitz

In Molecular Biology

1. S. Rajagopal
2. R. Gainetdinov
3. J. Beaulieu
4. R. J. Lefkowitz
5. K. Rajagopal
6. R. Hen
7. Heidi E. Hamm
8. J. Pober

Citations in the corpus

• Evolving functions of endothelial cells in inflammation (2007, background): “Signals by heterotrimeric GPCRs last for 10–20 minutes, after which the receptors become desensitized, preventing restimulatio”
• BEHAVIORAL EFFECTS OF FLUOXETINE IN AN ANIMAL MODEL OF ANXIETY/DEPRESSION ARE MEDIATED BY BOTH NEUROGENESIS-DEPENDENT AND INDEPENDENT MECHANISMS (2009, background): “Classical b-arrestin functions include desensitization of GPCRs (Gainetdinov et al., 2004), so it is possible that b-arrestin 2 may be important for desensitization of 5-HT1A receptors in the Raphe Nucleus, a process that has been hypothesized as necessary for the effects of fluoxetine (Artigas et a”
• The Physiology, Signaling, and Pharmacology of Dopamine Receptors (2011, background): “The possibility of the oligomerization of GPCRs further complicates this situation because of the variety of intracellular signaling events that might be evoked by heterodimers of receptors (Maggio et al., 2005; Fiorentini et al., 2010; Fuxe et al., 2010; Hasbi et al., 2010).”
• Teaching old receptors new tricks: biasing seven-transmembrane receptors (2010, background): “In addition, these knockout mice have a reduction in the typical novelty-induced locomotor hyperactivity phenotype of dopamine transporter knockout mic”
• Phosducin‐like protein acts as a molecular chaperone for G protein βγ dimer assembly (2005, background): “Heterotrimeric G proteins mediate a wide array of hormonal, neuronal and sensory signals that control numerous physio- logical processes ranging from cardiac rhythm (Rockman et al, 2002) to psychological behavior (Gainetdinov et al, 2004) to vision (Arshavsky et al, 2002).”