The probability of duplicate gene preservation by subfunctionalization.

By Michael Lynch, A. Force. Genetics, 2000

1,584 citations recorded by the source corpus.

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Citations in the corpus

Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, unknown): “The existence of multiple copies of one gene can lead to functional diversification, with one copy acquiring a new function (neofunctionalization) or a partitioning of expression patterns (subfunctionalization) that involves reciprocal (most likely epigenetic) silencing of each of the copies leading”
Splitting pairs: the diverging fates of duplicated genes (2002, methodology): “What alternatives exist to non-functionalization and neo-functionalization? A broadly applicable SUB-FUNCTIONALIZATION model was recently proposed by Force and colleagues to explain the prevalence of duplicate genes that are retained in the genom”
Polyploidy and angiosperm diversification. (2009, methodology): “The rapidly growing EST data sets for diverse angiosperms can be employed to assess ancient polyploidy using a genomics method to estimate whether a genome duplication event may have occurred in a lineage, as well as the approximate age of these gene duplication events ( Lynch and Conery, 2000 ).”
Gene co-expression network topology provides a framework for molecular characterization of cellular state (2004, background): “Freed from selective pressure, duplicated copies of pleiotropic genes may tend to lose sub-components of their original functions, reducing redundancy (Force et al., 1999; Lynch and Force, 2000).”
Evolutionary genetics of genome merger and doubling in plants. (2008, background): “This mode of subfunctionalization is of considerable evolutionary interest, as it may enhance the probability of duplicate gene retention (62) (see below) following polyploid formation (2, 86).”
Developmental Gene Evolution and the Origin of Grass Inflorescence Diversity (2006, background): “The sheer number of available genes and presumed gene functions may help explain the morphological variety that exists among grasses.”
The evolution of gene duplications: classifying and distinguishing between models (2010, background): “After degenerate mutations have been fixed in both copies by drift, neither copy is sufficient to perform the original function, and the two copies are subfunctionalized so that both must be maintained by selectio”
A gene for speed? The evolution and function of α‐actinin‐3 (2004, background): “This typeof differential lossof subfunctions is thought to be a common mechanism for the maintenance of duplicated genes in vertebrates, and allows greater freedom for functional specialisation during subsequent evolution.((62))”
Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae (2004, methodology): “However, this model has been contested by others, who argued that both copies would diverge more rapidly and acquire new function”
PGDD: a database of gene and genome duplication in plants (2012, background): “For the rare survivors, classical views suggest that GD is potentially advantageous as a primary source of genes with new (3,4) or modified functions (5).”
Archaeal Clusters of Orthologous Genes (arCOGs): An Update and Application for Analysis of Shared Features between Thermococcales, Methanococcales, and Methanobacteriales (2015, background): “In more general terms, this parsimonious scenario of enolase evolution corresponds to the subfunctionalization route of evolution whereby after gene duplication, the two paralogs retain complementary subsets of the ancestral gene functions while undergoing evolutionary acceleration caused by partial”
The evolutionary consequences of polyploidy. (2007, background): “or subfunctionalization (Force et al., 1999; Lynch and Force, 2000) of gene expression can prevent duplicated genes from accumulating mutations that eliminate function because the function of each gene copy is necessary at some time or place within the organism.”
The role of hybridization in plant speciation. (2009, background): “Lynch M, Force A. 2000.”