The ABC of APC.

By N. Fearnhead, M. Britton, W. Bodmer. Human Molecular Genetics, 2001

949 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/f59438e0e9fc57d695fa79d7f5454adb78839bc5

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In Molecular Biology

In Pathology and Forensic Medicine

K. Guan

Citations in the corpus

Colorectal cancer and genetic alterations in the Wnt pathway (2006, background): “The protein-truncating mutations can occur anywhere in the APC gene, but the classical phenotype of more than 100 adenomas is associated with mutations between codons 178 and 309 and between codons 409 and 1580, corresponding to exons 5–8, 9–14 and the first half of the large final exon 15 (Fearnhea”
Dysregulation of the TSC-mTOR pathway in human disease (2004, background): “The loss of APC causes β-catenin activation, resulting in upregulation of a series of proto-oncogenes such as cyclin D and c-my”
Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors (2002, background): “We have studied family N, which is affected with multiple colorectal adenomas and carcinoma but lacks an inherited mutation of the adenomatous polyposis coli gene ( APC ) that is associated with familial adenomatous polyposi”
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. (2002, background): “Indeed, mutational analysis of APC in cancer has shown that many APC mutations prohibit its engagement with axin but preserve -catenin association (Hart et al. 1998; Fearnhead et al. 2001).”
Base-excision repair of oxidative DNA damage (2007, background): “In familial adenomatous polyposis, the colon of afflicted individuals is littered with adenomatous polyps as a result of mutations in the gene adenomatous polyposis coli ( APC”