Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

By Bahareh Ajami, Jami L. Bennett, C. Krieger, W. Tetzlaff, F. Rossi. Nature Neuroscience, 2007

1,574 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/f5911b82f50ea6d80f88f33c69ca1cf419cf354e

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Citations in the corpus

The microenvironmental landscape of brain tumors (2017, background): “…has largely taken a different tack; as interest for immune checkpoint inhibitors in cancer therapy continues to expand, DC vaccines are likewise gaining significant clinical attention as an alternative strategy to stimulate T cell responses (Anguille et al., 2014; Palucka and Banchereau, 2012).”
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration (2011, result): “, this study convincingly showed that there were no bone marrow–derived phagocytes cells in the CNS of the GFP-negative partner under any tested conditions, including total-body irradiation of the parabiotic recipien”
Microglia states and nomenclature: A field at its crossroads (2022, neutral): “20 Microglia have the capacity for self-renewal in certain contexts, allowing them to repopulate the CNS within 1 week of depletion, even when more than 99% of microglia are ablated with CSF1R antagonists 21,22 or diphtheria toxin.”
Debris clearance by microglia: an essential link between degeneration and regeneration (2008, background): “In general microgliosis arises as a result of a proliferative response of resident microglia, present within the CNS due to invasion by myeloid precursors during development (Ajami et al., 2007; Ransohoff, 2007).”
Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus (2013, neutral): “Nevertheless, because it has been argued that the BM chimeric model (though without shielding) is confounded by some unavoidable artifacts (Ajami et al., 2007; Mildner et al., 2007), we confirmed our findings by experimental models that involved neither irradiation nor hematopoietic stem cell transp”
Microglia: biology and pathology (2009, background): “However, microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease conditions remains a controversial issue [1, 123].”
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation (2019, background): “Unlike most peripheral tissue macrophages, MG and most CAMs such as pvMF and mMF arise from Linc-Kit erythromyeloid progenitors in the YS during embryonic development and are maintained throughout life by self-renewal (40, 47) independent of bone-marrow precursor cells (45, 48).”
Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, background): “Similar results have been also observed for microglia (Ajami et al., 2007; Ginhoux et al., 2010), suggesting that both these popu-”
Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice (2009, background): “Two recent publications have questioned the use of BM chimeras in CNS studies [8,9]; irradiation, even in the absence of further injury, mobilized monocytes to the noninjured CNS.”