Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

By R. Shechter, Anat London, C. Varol, Catarina Rapôso, Melania Cusimano, Gili Yovel, A. Rolls, M. Mack, S. Pluchino, G. Martino and 2 more. PLoS Medicine, 2009

751 citations recorded by the source corpus.

Using a mouse model of spinal injury, Michal Schwartz and colleagues tested the effect of macrophages on the recovery process and demonstrate an important anti-inflammatory role for a subset of infiltrating monocyte-derived macrophages that is dependent upon their expression of interleukin 10.

Subfields: Immunology, Neurology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/70ebdbe277a694cf01c8d4093aa51e94db307625

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Neurology

In Pathology and Forensic Medicine

Citations in the corpus

Developmental and Functional Heterogeneity of Monocytes. (2018, background): “It has been shown that under mild inflammatory conditions mesenchymal stem cells and their progeny, including CXCL12-abundant reticular cells, represent the major source of CCL2 production in the BM (Shi and Pamer, 2011), although the situation might differ under healthy conditions.”
The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “Histological studies have found a concentration of microglia very early on in the lesion core (143, 326, 344) followed by their migration to the lesion’s margins later on (105).”
Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine (2012, background): “A small number of blood-derived monocytes have been observed to participate in the default tissue remodeling response in the CNS at late time points following injury, even in the absence of a breach of the bloodebrain barrier [129,130].”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “We will emphasize first that local inflammation and scar formation are both essential for survival, repair, and renewal, but that their regulation is often suboptimal (190, 212).”
Macrophages: development and tissue specialization. (2015, background): “Intestinal gut macrophages, for instance, express the IL-10 receptor and must be exposed to homeostatic T regulatory cell–derived IL-10 to prevent colitis (106).”
Microglial Activation & Chronic Neurodegeneration (2010, background): “For example, ablation of infiltrating bone marrow derived cells (that become microglia) in spinal cord injury at specific times has been shown to have disastrous neurotoxic consequences.(14) In addition, microglia have also been shown to release anti-inflammatory and trophic molecules to enhance the”
Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials (2015, background): “While removing bacteria and debris, they also release additional chemotactic molecules to recruit macrophages [82].”
Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “M2 alternatively activated macrophages contribute to neuronal repair in spinal cord injury models (Schwartz, 2010; Shechter et al., 2009) and play a role in stroke.”