Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

By E. Jho, Tong Zhang, C. Domon, C. Joo, J. Freund, F. Costantini. Molecular and Cellular Biology, 2002

1,751 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f4b43fe9e8ad8f7815e01a4f2542520c381b912f

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Citations in the corpus

• Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation (2003, background): “For instance, -catenin induces its own negative regulators Naked and Axin2 (Zeng et al., 2000; Jho et al., 2002).”
• Sumoylation is involved in β‐catenin‐dependent activation of Tcf‐4 (2003, background): “…increased the transcriptional activity of endogenous Tcf towards the cyclin D1 and Axin2 promoters, which are the natural Tcfresponsive promoters (Tetsu and McCormick, 1999; Jho et al., 2002; Lustig et al., 2002), but PIASyCA inhibited b-catenin-dependent activity of these promoters (Figure 7F).”
• An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules (2013, background): “, 1998) and AXIN2 expression levels (Figure S4B) (Jho et al., 2002).”
• Wnt signaling in development and tissue homeostasis (2018, background): “Both Axin1 and Axin2 are functionally equivalent proteins (Chia and Costantini, 2005) but, in contrast to its paralog Axin1 , which is expressed constitutively, Axin2 is a Wnt target gene (Jho et al., 2002; Lustig et al., 2002).”
• Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “In normal cells, as part of a negative feedback mechanism, Axin2 is upregulated following Wnt stimulation (Jho et al. 2002; Leung et al. 2002; Lustig et al. 2002).”
• Novel insights into Notum and glypicans regulation in colorectal cancer (2015, background): “In addition to the expected up-regulation of AXIN2, which is widely accepted to be an important downstream effector of the Wnt signaling cascade [16], a high number of other important targets and members of the Wnt signaling pathway were differentially expressed in adenocarcinoma.”
• Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. (2004, background): “Axin2 is induced by Wnt signaling, suggesting that Axin2 expression serves as a negative-feedback regulator of Wnt signaling (Jho et al. 2002; Leung et al. 2002).”
• Wnt/beta-catenin signaling in development and disease. (2006, neutral): “The best current candidates in vertebrates are Axin2/conductin (Jho et al., 2002) and SP5 (Weidinger et al.”
• Functional redundancy of GSK-3α and GSK-3β in wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines (2007, background): “Several target genes for LEF/TCF have been identified, including Axin-2, which is thought to function as a negative feedback regulator of Wnt signaling (Jho et al., 2002; Leung et al., 2002; Lustig et al., 2002).”
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way (2004, background): “In any event, one should keep in mind that, in mammalian cells, Wnt/βcatenin signaling induces the expression of an Axin homolog, Axin2 (also known as Axil/Conductin) (Behrens et al., 1998; Yamamoto et al., 1998; Yan et al., 2001; Jho et al., 2002; Leung et al., 2002; Lustig et al., 2002).”