Functional redundancy of GSK-3α and GSK-3β in wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines

By B. Doble, Satish Patel, G. Wood, Lisa Kockeritz, J. Woodgett. 2007

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Pi-Pi contacts are an overlooked protein feature relevant to phase separation (2018, background): “These orthologs are often functionally interchangeable (Doble et al., 2007), but there is evidence of isoform-specific roles for GSK3a (Ma, 2014) and the predicted differences could reflect a difference in modulating phase-separation behavior.”
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration (2009, background): “of wnt activity by PGE2 in HSCs, especially given a recently proposed functional redundancy of GSK3b with GSK3a (Doble et al., 2007).”
The GSK3 hypothesis of Alzheimer's disease (2008, background): “Recently, GSK3a in addition to GSK3b, has been shown to function in the destruction complex and the Wnt signaling pathway, suggesting that this enzyme is equally as important in Wnt biology as is GSK3b (Asuni et al. 2006; Doble et al. 2007).”