The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses.

By F. Zalfa, M. Giorgi, B. Primerano, A. Moro, A. di Penta, Surya A. Reis, B. Oostra, C. Bagni. Cell, 2003

689 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f3dff50ae6b00b7bc507e4dc6e09dbd18aedbd11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Mauro Costa-Mattioli
2. Nahum Sonenberg
3. Tilmann Achsel
4. C. Bagni
5. Wolf Reik
6. Silvia De Rubeis
7. Frederica Perera
8. Julie Herbstman

In Molecular Biology

1. C. Bramham
2. J. Shepherd
3. D. Wells
4. Mauro Costa-Mattioli
5. Richard L. Huganir
6. Pierre Marie Lledo
7. Nahum Sonenberg
8. Chris P. Ponting

Citations in the corpus

• Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb (2011, background): “…the scaffolding proteins of the postsynaptic density could also be involved in these spine architectural defects, such as PSD95 (Todd et al., 2003; Zalfa et al., 2003; Muddashetty et al., 2007), Shank1 (Schütt et al., 2009), and Sapap3/4 (Brown et al., 2001; Kindler et al., 2004; Narayanan et…”
• Pten regulates neuronal arborization and social interaction in mice. (2006, neutral): “Both FMR1 and the mTOR/S6K pathway regulate protein translation and synaptic plasticity (Tang et al., 2002; Zalfa et al., 2003).”
• Role of Purα in targeting mRNA to sites of translation in hippocampal neuronal dendrites (2006, background): “It is precisely those regions that are homologous to the mRNA molecules that are reportedly synaptically targeted by BC1 (Zalfa et al., 2003).”
• Identification of a cis‐acting element required for dendritic targeting of activity‐regulated cytoskeleton‐associated protein mRNA (2005, background): “the RNA-transporting granule include a complementary sequence to small dendritic RNA BC1, which interacts with FMRP (at nt 1957–67; Zalfa et al., 2003) and AU-rich elements (Tebo et al.”
• Dendritic mRNA: transport, translation and function (2007, background): “Indeed, both CPEB1 and FMRP associate with αCaMKII mRNA in neuron”
• Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. (2008, neutral): “, 2007) serve to reconcile past observations of translational excess at steady state (Lu et al., 2004; Zalfa et al., 2003) with reports of deficient mGluR-induced protein synthesis (Todd et al.”
• Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. (2006, background): “1 expression has been observed in Fragile X mental retardation (Zalfa et al., 2003) and Alzheimer’s disease (Dickey et al., 2003; Palop et al., 2005).”
• The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. (2008, background): “Moreover, BDNF activates the translation of Arc and aCaMKII mRNAs in dendrites and at synapses (Aakalu et al., 2001; Yin et al., 2002; Schratt et al., 2004).”
• Evolution and functions of long noncoding RNAs. (2009, background): “The neural phenotype of BC1 is consistent with its known interaction with both FMRP, the product of the fragile X mental retardation gene (FMR1), and with mRNAs regulated by FMRP (Zalfa et al., 2003).”
• Translational control of long-lasting synaptic plasticity and memory. (2009, neutral): “One model posits that FMRP regulates translation of its target mRNAs via interaction with the noncoding neuronal RNA BC1 (Zalfa et al., 2003).”