Dendritic mRNA: transport, translation and function

By C. Bramham, D. Wells. Nature Reviews Neuroscience, 2007

633 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/64c742ad8cbf5ca95a6c2ebe25b49a02e7092c3c

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In Cellular and Molecular Neuroscience

B. Lu

In Molecular Biology

Citations in the corpus

Dendritic excitability and synaptic plasticity. (2008, neutral): “Dendrites are equipped with protein synthesis capabilities, which are regulated through neuromodulation and neuronal activity, allowing more local control of the type and amount of proteins expressed in dendrites (88, 752).”
A census of human RNA-binding proteins (2014, background): “Furthermore, the considerable length of neuronal projections makes mRNA transport and local translation at neuronal dendrites indispensable for development, synaptic plasticity, and long-term memory (Bramham and Wells, 2007).”
Spatially restricting gene expression by local translation at synapses (2010, neutral): “In mature vertebrate neurons, most studies have focused on dendritically localized transcripts whose translation is regulated by stimuli that produce changes in synaptic efficacy [16–18], although translation in axons of mature vertebrate neurons is known to be required for neural regeneration follo”
Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity (2008, neutral): “…complex containing Maskin and eIF4E that regulates translation of proteins (e.g., aCaMKII, insulin receptor substrate protein 53, tissue plasminogen activator, AMPA receptor binding protein) (Bramham and Wells, 2007), several of which are involved in synaptic development and/or plasticity.”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “In this case, it is not a protein but mRNA that needs to be transported to the synapse (Bramham and Wells, 2007; Martin and Zukin, 2006; Sutton and Schuman, 2006).”
Brain-derived Neurotrophic Factor Promotes Differentiation and Maturation of Adult-born Neurons Through GABAergic Transmission (2012, background): “Local protein synthesis in dendrites has been shown to be crucial for lasting long-term potentiation and long-term depression in hippocampal slices (Bramham and Wells, 2007; Waterhouse and Xu, 2009).”
Past, present, and future of circRNAs (2019, neutral): “Local translation of circRNAs could be potentially important in synapses where other RNAs are translated (Bramham & Wells, 2007).”
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. (2008, neutral): “…polyribosomes within spines have driven studies to find numerous mRNAs that are selectively transported into dendrites and translated at synapses (Bramham and Wells, 2007), the identity of specific mRNA-binding proteins that play a direct role in mRNA transport or translational regulation…”