Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.

By G. Bassell, S. Warren. Neuron, 2008

1,057 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bb9fbfe5ec5b926d783acd44d44c5402d4a24d2a

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Citations in the corpus

Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb (2011, background): “As Fmrp is involved in the regulation of synaptic plasticity (Bear et al., 2004; Bassell and Warren, 2008), it would be interesting to test the effects of Fmrp loss on a form of plasticity of GCs that we have previously described (Nissant et al.”
Advancing the understanding of autism disease mechanisms through genetics (2016, positive): “Other ASD risk loci, including FMR1 , which encodes fragile X mental retardation protein (FMRP) that also regulates neuronal translation 180 , and dup15q11-q13, which contains the FMRP interactor and translational repressor cytoplasmic FMR1-interacting protein 1 ( CYFIP1 ) 181,182 , also suggest…”
mRNA Localization: Gene Expression in the Spatial Dimension (2009, positive): “Mutations in Fragile X Mental Retardation Protein (FMRP) are the cause of the most common form of X-linked mental retardation (for review, see Bassell and Warren, 2008).”
Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation (2013, background): “Consequently, these events recruit additional ribosomes to up-regulate mRNA translation of LTM-related proteins (42), which eventually lead to an enhanced response to the CS+.”
Consensus Paper: Pathological Role of the Cerebellum in Autism (2012, background): “FMRP, translated from the fragile X mental retardation-1 (FMR1) gene, is an RNA-binding protein involved in posttranscriptional regulation of target RNAs [157] and binds approximately 4% of the mRNA expressed in the brain [158].”
Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning (2011, positive): “Fmrp is enriched in neurons, so the learning deficits of people with FXS and Fmrp-deficient mice are widely believed to result from a deficiency in the synaptic plasticity of mature neuron”
Mutations causing syndromic autism define an axis of synaptic pathophysiology (2011, background): “Fragile X is caused by the loss of FMRP, an mRNA-binding protein that negatively regulates translatio”
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. (2010, positive): “Fragile X syndrome (FXS), the most common inherited cause of mental retardation (Bagni and Greenough, 2005; Bassell and Warren, 2008), is usually due to a trinucleotide expansion in the FMR1 gene that results in transcriptional silencing of FMRP (fragile X mental retardation protein) expression.”
Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells (2010, background): “Evidence suggests that Fmrp is involved in the post-transcriptional regulation of protein synthesis [2–4].”