Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors.

By J. Shepherd, Gavin Rumbaugh, Jing Wu, Shoaib Chowdhury, N. Plath, Dietmar Kuhl, Richard L. Huganir, P. Worley. Neuron, 2006

799 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/cab650b968752184881d4045a995f6cdbda9d245

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Citations in the corpus

The Angelman Syndrome-associated ubiquitin ligase Ube3A regulates synapse development by ubiquitinating Arc (2010, neutral): “regulated by neuronal activity and by Arc (Newpher and Ehlers, 2008; Kessels and Malinow, 2009; Rial Verde et al, 2006; Shepherd et al., 2006).”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (positive): “Several groups have found evidence for postsynaptic changes in the densities of both AMPA receptors (Lissin et al., 1998; O’Brien et al., 1998; Turrigiano et al., 1998; Wierenga et al., 2005; Shepherd et al., 2006; Stellwagen and Malenka, 2006) and NMDA receptors (Rao and Craig, 1997; Watt et al.”
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement. (2011, background): “Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation.”
The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses (2008, neutral): “…synapses onto hippocampal CA1 neurons is mediated through rapid calcium-dependent insertion and synaptic accumulation of AMPA receptors, through a process that requires regulatory sequences on the GluR1, but not the GluR2, subunit (Hayashi et al., 2000; Malinow and Malenka, 2002; Shi et al., 2001).”
Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity (2008, background): “1, an immediate-early gene that is rapidly induced by neuronal activity associated with information encoding in the brain (Guzowski et al., 2005), modulates homeostatic plasticity through a direct interaction with the endocytic pathway (Shepherd et al., 2006).”
Rapid synaptic scaling induced by changes in postsynaptic firing. (2008, background): “Several signaling molecules have been suggested to mediate or modulate synaptic scaling (Goddard et al., 2007; Rial Verde et al., 2006; Rutherford et al., 1998; Shepherd et al., 2006; Stellwagen and Malenka, 2006), including the Calcium/calmodulindependent protein kinases (CaMKs; Thiagarajan et al.”
Regulatory mechanisms of AMPA receptors in synaptic plasticity (2007, background): “1 ), an immediate-early gene that regulates components of the endocytosis machinery (namely endophilin 3 and dynamin 2), can contribute to homeostatic scaling by regulating endocytosis of GluR2-/GluR3-containing AMPAR”
Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex. (2008, neutral): “Organotypic slice cultures were prepared from coronal slices of visual cortex of P4‐5 mice essentially as described ( Schluter et al., 2006 ).”
The cell biology of synaptic plasticity: AMPA receptor trafficking. (2007, neutral): “The IEG Arc has also been implicated in regulating AMPAR scaling (Shepherd et al. 2006).”
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. (2006, background): “However, when Arc/Arg3.1 is expressed in WT neurons, we see downregulation of both GluR1 and GluR2 ( Shepherd et al., 2006 [this issue of Neuron]; Figure 2C).”