HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.

By S. Migueles, M. Sabbaghian, W. Shupert, M. Bettinotti, F. Marincola, Lisa Martino, C. Hallahan, S. Selig, David C. Schwartz, J. Sullivan and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,098 citations recorded by the source corpus.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/f3ad7b418b1d0fd4a72f41f8f4ee6ac1a31861c3

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In Immunology

1. Steven G. Deeks
2. Daniel C. Douek
3. R. Koup
4. J. McCune
5. Mario Roederer

In Virology

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Citations in the corpus

• Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level (2002, background): “individuals treated with antiretroviral therapy during acute infection, even transiently, have improved disease outcome and characteristics similar to long-term nonprogressors.(344,426,429,827,834) This appears to be largely due to the preservation of HIV-1specific CD4+ T-helper cells.”
• Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA (2004, result): “These conclusions are supported by previous studies in B-clade infected Caucasians which show that HLA-B alleles are most closely associated with non-progression/low viral loa”
• Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. (2008, background): “For example, controllers have much stronger polyfunctional HIV-specific CD8+ T cell responses than chronically HIV-infected patients maintaining antiretroviral treatment–mediated viral suppression [5], and they are enriched for protective class I HLA haplotypes associated with delayed disease progre”
• Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control (2008, methodology): “HLA typing was performed by sequence-specific hybridization as described previously (Migueles et al., 2000).”
• Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4+ and CD8+ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection (2001, background): “Given the associations between rapid progression or nonprogression and HLA haplotype (21, 31), it is also possible that recognition of particular HIV epitopes in context of certain HLA molecules plays a significant role in the ability of CD8 T cells to control viral replication (28).”
• HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors (2002, background): “, was found to be over-represented (14 of 16) among an expanded group of these LTNP”
• Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study (2013, background): “Protective HLA class I alleles (HLA-B*27 and B*57) have been consistently found to be overrepresented in cohorts of HICs [17,18,19] who spontaneously control HIV-1 infection.”