Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy.

By P. Hunt, J. Brenchley, E. Sinclair, J. McCune, M. Roland, K. Page-Shafer, P. Hsue, B. Emu, M. Krone, H. Lampiris and 3 more. Journal of Infectious Diseases, 2008

681 citations recorded by the source corpus.

Subfields: Emergency Medicine, Infectious Diseases, Virology

View Paper: https://www.semanticscholar.org/paper/0874c13bb301da8678dfa64ef7c77214e35ff8a8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. A. Haase
2. Mario Roederer
3. Daniel C. Douek
4. R. Koup
5. A. Khoruts

In Virology

1. A. Haase
2. Mario Roederer
3. Daniel C. Douek
4. R. Koup
5. John C. Mingers
6. Leroy White

Citations in the corpus

• Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues (2014, background): “Levels of T-cell activation and innate system activation are often higher than that observed in well-matched uninfected adults (5, 6).”
• Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral-Treated HIV Infection (2009, neutral): “Our data [7, 18], as well as emerging data from other investigators [25], indicate that bacterial products (LPS and bacterial DNA) are often circulating in the plasma of HIV-infected patients.”
• Emerging Concepts in the Immunopathogenesis of AIDS (2009, background): “These findings suggest that plasma LPS, in addition to its potent immunostimulatory activity through Toll-like receptor 4 (TLR-4), is also an indicator of the translocation of additional microbial products that stimulate the immune system through other receptors.”