Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level

By C. Moore, M. John, I. James, F. Christiansen, C. Witt, S. Mallal. Science, 2002

821 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/93fa713a199c5563f89d95d73b6a1b17102dc19c

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In Immunology

In Virology

Citations in the corpus

The Evolution and Emergence of RNA Viruses (2009, background): “The most provocative idea is that CTL escape mutations that are benefi cial within hosts are also favourably transmitted at the population level, leading to epidemiological scale adaptation (Moore et al. 2002; Trachtenberg et al. 2003).”
Biological and biomedical implications of the co-evolution of pathogens and their hosts (2002, background): “There is also some evidence for a potentially co-evolutionary interaction between HIV-1 and human CTL response”
MHC polymorphism under host-pathogen coevolution (2004, background): “HIV-1 has also evolved protein regions devoid of T-cell epitopes, because they lack immuno-proteasome cleavage sites, generate peptides that are poorly presented by MHC molecules, or evade effective immune responses (Korber et al. 2001; Moore et al. 2002; Yusim et al. 2002).”
The causes and consequences of HIV evolution (2004, background): “As a consequence, HIV strains might not readily adapt to the HLA HAPLOTYPE distributions of their local population”
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA (2004, methodology): “To investigate further the differential impact of class I loci on HIV-1 sequence polymorphism, we analysed a previously reported cohort from Western Australi”
Major Histocompatibility Complex Genomics and Human Disease (2013, neutral): “Several papers have pointed to escape variants of HIV-1 through the generation of peptide sequences that evade T cell recognition or influence KIRs or LILRs (15, 53, 75, 87).”
Adaptive immune responses in acute and chronic hepatitis C virus infection (2005, background): “Escape mutations within HIV epitopes restricted by common MHC class I alleles may impart a ‘footprint’ of associated polymorphisms upon viral species within a populatio”
An Evolutionary-Network Model Reveals Stratified Interactions in the V3 Loop of the HIV-1 Envelope (2007, result): “This phenomenon has more recently been found to substantially alter the results of a landmark study into genetic associations of HIV-1 escape from cytotoxic T lymphocytes in a human population [33,34].”