Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA

By P. Kiepiela, A. Leslie, I. Honeyborne, Danni Ramduth, C. Thobakgale, Senica Chetty, Prinisha Rathnavalu, C. Moore, K. Pfafferott, L. Hilton and 18 more. Nature, 2004

891 citations recorded by the source corpus.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/ca105d4c2eca734eed3a93df44db9d79ab520659

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Steven G. Deeks
2. Daniel C. Douek
3. Peter Parham
4. J. McCune
5. Mario Roederer

In Virology

1. Daniel C. Douek
2. Steven G. Deeks

Citations in the corpus

• Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. (2008, background): “For example, controllers have much stronger polyfunctional HIV-specific CD8+ T cell responses than chronically HIV-infected patients maintaining antiretroviral treatment–mediated viral suppression [5], and they are enriched for protective class I HLA haplotypes associated with delayed disease progre”
• CD8+ T-cell responses to different HIV proteins have discordant associations with viral load (2007, background): “These responses, defined through strong statistical associations after correction for multiple comparison”
• Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 (2007, background): “and is also the most consequential in the acquired immune response against HIV from both functional and genetic epidemiological perspective”