Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4+ and CD8+ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

By M. Betts, D. Ambrozak, Daniel C. Douek, Sebastian Bonhoeffer, J. Brenchley, J. Casazza, R. Koup, L. Picker. Journal of Virology, 2001

780 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Virology

View Paper: https://www.semanticscholar.org/paper/5ab8c57b8df71c70dd5560753f8b160d072c4aeb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Mario Roederer
2. Daniel C. Douek
3. R. Koup
4. R. Seder
5. V. Appay
6. D. Sauce

In Infectious Diseases

1. Mario Roederer
2. Daniel C. Douek
3. R. Koup
4. V. Appay
5. D. Sauce

In Virology

1. Mario Roederer
2. Daniel C. Douek
3. R. Koup
4. V. Appay
5. D. Sauce

Citations in the corpus

• Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load (2003, background): “While some previous studies have suggested that the number of HIV-1-specific CD8 T cells inversely correlates with the plasma viral load (19, 37, 46), others have found no such correlation (16, 21), and more comprehensive studies have found a positive correlation between specific CD8-T-cell frequenc”
• Emerging Concepts in the Immunopathogenesis of AIDS (2009, positive): “A number of studies demonstrate that the magnitude of the CD8 T cell response to HIV does not correlate with or predict progression (62, 63).”
• Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects (2005, result): “, Herpes simplex, Herpes zoster [9, 11, 15, 28–30]) and are comparable with frequencies of HIV-specific T cells in active HIV infection (31).”
• HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors (2002, background): “By flow cytometry–based intracellular cytokine detection or major histocompatibility complex (MHC) tetramer staining, no quantitative differences in HIV-specific responses between HLA-B a 5701 + LTNPs and HLA-B a 5701 + or HLA-B a 5701 − patients with progressive infection have been foun”
• Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “HIVspecific CD4+ T cell responses are usually present at a lower magnitude (ie up to 3% of circulating CD4+ T cells) [30], which may be related to their preferential depletion by the virus [32].”
• T-cell quality in memory and protection: implications for vaccine design (2008, background): “First, although CD8 + T-cell responses are crucial for controlling HIV infection, the magnitude of such responses does not correlate with disease progressio”
• Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control (2008, positive): “The frequency of HIV-specific CD8 T cells in the peripheral blood of LTNPs is no different from that of untreated progressors (Betts et al., 2001; Gea-Banacloche et al., 2000; Migueles et al., 2002).”