HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

By S. Migueles, Alisha C. Laborico, W. Shupert, M. Sabbaghian, R. Rabin, C. Hallahan, D. Baarle, S. Kostense, F. Miedema, M. McLaughlin and 4 more. Nature Immunology, 2002

1,114 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Virology

View Paper: https://www.semanticscholar.org/paper/7a09eae684f311fbecc4afe3bf035e77242e212d

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In Immunology

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Citations in the corpus

• Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. (2005, background): “In addition, HIV long-term nonprogressors were associated with HIV-specific CD8+ T cells characterized by less-differentiated phenotype (CD45RO+/CD27+/CD28+) and high proliferative capacity (51).”
• Lineage relationship and protective immunity of memory CD8 T cell subsets (2003, background): “Consistent with this idea, the proliferative capacity of HIV-specific CD8 T cells is significantly greater in long-term nonprogressors who maintain HIV control than in other HIV + individual”
• Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “For instance, long-term nonprogression may be established through the action of certain populations of HIV-specific CD8+ T cells that display polyfunctional characteristics [69] and/or proliferative capacity [70], and are able to maintain low viral load in infected patients.”
• PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection (2006, background): “HIV-specifi c CD8+ T cells are characterized by limited proliferative capacity in chronic HIV infection (38, 39), a defect that is linked to the depletion of IL-2–secreting HIV-specifi c CD4+ and/or CD8+ T cells (7, 39, 40).”
• Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 (2007, background): “, the Massachusetts General Hospital (MGH) Controller Cohort, and the NIAID long term nonprogressor cohor”
• T-cell quality in memory and protection: implications for vaccine design (2008, background): “Functional heterogeneity of T-cell responses Much of the data that correlates T-cell quality with clinical outcome has been generated from studies on HIV infectio”
• Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control (2008, methodology): “CD4+ T cells were positively selected from cryopreserved PBMCs by magnetic automated cell sorting (AutoMACS, Miltenyi Biotec, Auburn, CA, USA) and polyclonally stimulated prior to infection as previously described (Migueles et al., 2002; Sacha et al., 2007).”