Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

By Andreas Meyer-Lindenberg, R. Miletich, P. Kohn, G. Esposito, R. Carson, M. Quarantelli, Daniel R. Weinberger, Karen Faith Berman. Nature Neuroscience, 2002

680 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/f2e50862033a700d8cd846ae2a8e9970177315c1

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Psychiatry and Mental health

Citations in the corpus

Glutamate and dopamine in schizophrenia: an update for the 21st century (2015, background): “…with some studies not finding significant differences from controls (Dao-Castellana et al., 1997; Elkashef et al., 2000; Shotbolt et al., 2011) whilst others have detected significant elevations (Howes et al., 2013a; McGowan et al., 2004; Meyer-Lindenberg et al., 2002; Reith et al., 1994).”
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. (2004, background): “neuroimaging measures of abnormal prefrontal cortical neuronal function in the same subjects [ 71 ,72].”
Dysfunction of ventral striatal reward prediction in schizophrenia (2006, background): “…neurobiological correlates of cognitive dysfunction in prefrontal – striatal – thalamic neurocircuits (Andreasen et al., 1996; Callicott et al., 2000; Meyer-Lindenberg et al., 2002, 2005; Abi-Dargham et al., 2002; Molina et al., 2003), only a few imaging studies have examined the central…”
Intermediate phenotypes and genetic mechanisms of psychiatric disorders (2006, methodology): “After briefly recapitulating the development of the intermediate phenotype concept, we review recent advances in the characterization of prefrontal circuits in schizophreni”
The dopamine hypothesis of schizophrenia: version III--the final common pathway. (2009, neutral): “There is of course correlational evidence that striatal dopamine abnormalities are associated with poor performance on cognitive tasks(17,20,168) and suggestion that higher striatal dopamine synthesis capacity is linked to functional abnormalities in the cortical regions engaged by these tasks.(168,”
Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior (2005, background): “Disruption of this balance may be one of the central components in the pathophysiology of schizophreni”