Dysfunction of ventral striatal reward prediction in schizophrenia

By Georg Juckel, Florian Schlagenhauf, M. Koslowski, Torsten Wüstenberg, Arno Villringer, Brian Knutson, Jana Wrase, Andreas Heinz. NeuroImage, 2006

611 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/8c63016fe564a141770f6bc03454d67f72eb52f6

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Psychiatry and Mental health

Citations in the corpus

Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression (2008, background): “Human neuroimaging studies have shown that the ventral striatum is very active during rewardseeking behaviors (Juckel et al, 2006; Knutson et al, 2001b, 2003), and this activation is reduced in certain clinical populations; for example, patients with schizophrenia (Juckel et al, 2006).”
Positive Emotions Broaden and Build (2012, result): “Both self-report and fMRI data support this distinction (Gard, Kring, Gard, Horan, & Green, 2007; Juckel et al., 2006).”
Glutamate and dopamine in schizophrenia: an update for the 21st century (2015, background): “There is certainly evidence that untreated and drug-naïve patients with schizophrenia show alterations in processing motivationally salient stimuli (Juckel et al., 2006; Nielsen et al., 2012; Schlagenhauf et al., 2009).”
Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction Errors (2008, background): “…brain computes different value signals in the context of decision making might also help to determine the mechanisms underlying altered reward processing in neuropathologies like depression, and schizophrenia (Tremblay et al., 2005; Forbes et al., 2006; Juckel et al., 2006; Murray et al., 2008).”
The dopamine hypothesis of schizophrenia: version III--the final common pathway. (2009, positive): “As an explanation, this has face validity, and there is some evidence that schizophrenia is associated with reduced ventral striatal activation to reward, and greater reduction is related to higher levels of negative symptoms.(163)”
Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia (2009, background): “There is also evidence that this system is disrupted in schizophrenia: the ventral striatum (a key component of the mesolimbic dopamine circuit) was shown to be under-active in response to rewarding experiences in patient”
Anticipatory affect: neural correlates and consequences for choice (2008, neutral): “Dillon et al. (2008)AB xxxx Juckel et al. (2006) A xx”
The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques (2009, background): “…emerging evidence from neuroimaging studies in clinical samples indicates that anhedonic symptoms are linked to reward responses in key nodes of the reward system (Epstein et al., 2006; Juckel et al., 2006a, 2006b; Keedwell et al., 2005; Mitterschiffthaler et al., 2003; Tremblay et al., 2005).”
Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study (2011, background): “…understanding abnormalities associated with a number of psychopathologies including addiction (see Nestler, 2005 for review), schizophrenia (e.g., Juckel et al., 2006; Simon et al., 2010; Wacker et al., 2009), and depression (reviewed by Fitzgerald et al., 2008; Martin-Soelch, 2009; Nestler and…”