Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior

By Yukiori Goto, Anthony A. Grace. Nature Neuroscience, 2005

605 citations recorded by the source corpus.

Goal-directed behavior is believed to involve interactions of prefrontal cortical and limbic inputs in the nucleus accumbens (NAcc), and their modulation by mesolimbic dopamine (DA) seems to be of primary importance in NAcc function. Using in vivo electrophysiological recordings simultaneously with DA system manipulation in rats, we show that tonic and phasic DA release selectively modulates hippocampal and prefrontal cortical inputs through D1 and D2 receptors, respectively. In addition, we also found that D1 activation and D2 inactivation in the NAcc produced behaviorally selective effects (learning versus set shifting of response strategy) that correspond to specific afferents. These results suggest that the dynamics of DA release regulate the balance between limbic and cortical drive through activation and inactivation of DA receptor subtypes in the accumbens, and this regulates goal-directed behavior.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/13508315bbc82dc1e5c72547bdd534292c2e3675

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Citations in the corpus

Neurocircuitry of Mood Disorders (2010, background): “Finally, the cognitive and behavioral response patterns supporting goal- or reward-directed activity are thought to depend upon PFC inputs to the ventral striatum, which are maintained or ‘gated’ by projections from the hippocampus (subiculum) to the ventral striatum (Goto and Grace, 2005).”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, positive): “Therefore, activation of one afferent system will attenuate afferent drive from the alternate system (Goto and Grace, 2005a).”
Tonic dopamine: opportunity costs and the control of response vigor (2007, positive): “, the pedunculopontine nucleus and the ventral pallidum, respectively) appear to affect either bursting activity or population activity in dopamine neurons (Floresco et al. 2003; Goto and Grace 2005; Lodge and Grace 2006), providing another mechanism for independent modulation of phasic and tonic do”
Reinforcement learning in the brain (2009, background): “It suggests that the input that dopaminergic neurons receive from their diverse afferents (which include the medial prefrontal cortex, the nucleus accumbens shell, the ventral pallidum, the central nucleus of the amygdala, the lateral hypothalamus, the habenula, the cholinergic pedunculopontine nucl”
Computational models of reinforcement learning: the role of dopamine as a reward signal (2010, background): “…to in the literature, evidences for tonic changes in DA concentrations (e.g. long lasting, timescales of seconds to minutes) have also been reported in vivo, in the basal ganglia and in prefrontal cortices (PFC; Bergstrom and Garris 2003; Floresco et al. 2003; Goto and Grace 2005; Grace 1991).”
Model-Based and Model-Free Pavlovian Reward Learning: Revaluation, Revision and Revelation (2014, background): “…signals the average reward (Daw, Kakade, & Dayan, 2002; although tonic and phasic dopamine activity may be under somewhat separate control—see Floresco, West, Ash, Moore, & Grace, 2003; Goto & Grace, 2005), and it is not clear whether there is also a model-based contribution to this average.”
The mysterious motivational functions of mesolimbic dopamine. (2012, positive): “Fluctuations in DA activity can take place over multiple timescales, and a distinction often is made between ‘‘phasic’’ and ‘‘tonic’’ activity (Grace, 2000; Floresco et al., 2003; Goto and Grace, 2005).”
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion (2005, background): “This interaction is modulated by mesolimbic dopamine and, in turn, can modulate the release of dopamin”
The debate over dopamine’s role in reward: the case for incentive salience (2007, background): “…balance between up states and resting states of neurons in nucleus accumbens or other structures that feed forward into altered inputs into the ventral pallidum or direct dopamine modulation of the ventral pallidum itself (Goto and Grace 2005; Kelley 2004a; O'Donnell 2003; Onn et al. 2000).”
Anatomy of a decision: striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal. (2006, neutral): “Goto & Grace, 2005).”