A brain-specific microRNA regulates dendritic spine development

By G. Schratt, Fabian Tuebing, E. Nigh, Christina G. Kane, M. Sabatini, M. Kiebler, Michael E. Greenberg. Nature, 2006

1,885 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f2c75b73bf429951a2ed76ab87a8e6f622dcd1ce

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Citations in the corpus

Translational control of long-lasting synaptic plasticity and memory. (2009, positive): “Neuronal activity such as BDNF treatment derepressed the miR-134-mediated translation inhibition of Limk1 mRNA (Schratt et al., 2006).”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “Reversibility of miRNA-mediated repression Recent findings indicate that under certain conditions, or in specific cells, miRNA-mediated repression can be effectively reversed or prevente”
Origin, biogenesis, and activity of plant microRNAs. (2009, positive): “In the second theoretical regulatory state (Figure 2A, left panel), miRNAs would mainly repress target protein production in a reversible manner, as inferred from studies in metazoans (Bhattacharyya et al., 2006; Schratt et al., 2006).”
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. (2007, background): “, 2004), relatively little is known about their functions (Ashraf et al., 2006; Chang et al., 2004; Kosik, 2006; Li et al., 2006; Schratt et al., 2006).”
A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. (2006, result): “Finally, we note that the recently reported miR-134 binding site in limk1 (Schratt et al., 2006) is among the set of rna22 ’s predictions but had not been included in the randomly selected set with which we experimented.”
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020, background): “BDNF is able to relieve the inhibition of LIM kinase 1 translation, and in this manner contribute to synaptic development, maturation and/or plasticity [56].”
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus (2007, methodology): “1) [2,3] and human 5S ribosomal RNA (5S rRNA) were spotted onto GeneScreen Plus nylon membranes using a Biomek 2000 laboratory automation workstation (Beckmann, Fullerton, California, USA) and were crosslinked, baked, hybridized and probed according to the manufacturer’s protocol (NEN Research Produ”
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. (2008, positive): “…models of FXS, including morphologic , physiological, and behavioral impairments, have been corrected either by administration of MPEP, an mGluR5 antagonist (McBride et al., 2005; Tucker et al., 2006; Yan et al., 2005), or genetic reduction of mGluR5 (Dolen et al., 2007; Bassell and Gross, 2008).”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “2006), CNS development (Schratt et al. 2006), and embryogenesis (Wienholds et al.”
Spatially restricting gene expression by local translation at synapses (2010, positive): “Consistent with this hypothesis, Schratt and colleagues have shown that miR-134 colocalizes with and regulates translation of the mRNA encoding LIM kinase (LIMK), an actin-binding kinase that phosphorylates members of the ADF/ cofilin family of actin binding and filament severing proteins, whose exp”