Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus

By Walter J. Lukiw. NeuroReport, 2007

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Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression (2008, background): “Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer’s disease hippocampus.”
The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (2008, background): “Previous studies demonstrated that a subset of miRNAs show altered expression in advanced AD, and these changes may be stimulated by reactive metal elements in the brain (Lukiw, 2007; Lukiw and Pogue, 2007).”
The Role of MicroRNAs in Human Diseases (2010, methodology): “The results of the expression profiling showed that miR-9, miR-128a and miR-125b are elevated in AD hippocampus (Table 4) (140) .”
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways (2008, positive): “While this paper was being prepared the altered expression of a limited set of miRNAs in AD hippocampus was reported [44].”