Spatially restricting gene expression by local translation at synapses

By D. Wang, K. C. Martin, R. Zukin. 2010

196 citations recorded by the source corpus.

mRNA localization and regulated translation provide a means of spatially restricting gene expression within each of the thousands of subcellular compartments made by a neuron, thereby vastly increasing the computational capacity of the brain. Recent studies reveal that local translation is regulated by stimuli that trigger neurite outgrowth/collapse, axon guidance, synapse formation, pruning, activity-dependent synaptic plasticity, and injury induced axonal regeneration. Impairments in the local regulation of translation result in aberrant signaling, physiology, and morphology of neurons, and are linked to neurological disorders. This review highlights current advances in understanding how mRNAs are translationally repressed during transport and how local translation is activated by stimuli. We address the function of local translation in the context of fragile X mental retardation.

Subfields: Genetics, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Neelroop Parikshak
2. Michael Jeffrey Gandal
3. Richard G. M. Morris
4. Daniel H. Geschwind

In Molecular Biology

1. Michael Jeffrey Gandal
2. Neelroop Parikshak
3. Richard G. M. Morris
4. Daniel H. Geschwind

Citations in the corpus

• Making memories last: the synaptic tagging and capture hypothesis (2010, background): “As there are intricate regulatory mechanisms capable of repressing mRNA translation until they reach appropriate (that is, tagged) synapse”
• Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015, background): “Locally regulated translation of these subcellular transcriptomes 210 has a crucial role in synaptic function and plasticity 211 .”