Foxp3-dependent programme of regulatory T-cell differentiation

By M. Gavin, J. P. Rasmussen, J. Fontenot, V. Vasta, V. Manganiello, J. Beavo, Alexander Y. Rudensky. Nature, 2007

1,202 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f23eb4cf990b98e23ad113c14b1a795f00a863a3

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Citations in the corpus

Regulatory T Cells: Mechanisms of Differentiation and Function (2012, methodology): “Finally, further support for a role of TCR signaling in this process comes from two experiments: (a) in mice harboring a Foxp3 reporter null allele (Foxp3GFPKO) that was generated upon insertion of a GFP coding sequence into the Foxp3 locus with a concomitant ablation of the Foxp3 protein expression”
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation (2007, background): “The transcription factor Foxp3 has been identified as crucial for the commitment of thymocytes to the T-reg lineag”
A two-step process for thymic regulatory T cell development. (2008, background): “Thus, the administration of a single cytokine to precursors within the CD25hi subset is sufficient for inducing Foxp3, the final step in Treg cell development (Gavin et al., 2007).”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “However, Foxp3 protein itself appears to be required for the heritable maintenance of Foxp3 expression, but does not augment the expression level of Foxp3 on a per cell basis, suggesting existence of a feed-forward regulatory loop (Figure 2; Gavin et al., 2007).”
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression (2007, background): “Gavin et al. ( 8 ) predict from gene clustering models that there are at least three potential T reg cell mechanisms inclusive of “suppressive soluble factors, generation of extracellular adenosine and release of reactive oxygen.” We demonstrate in this study that alterations in pericellular levels ”
Immune Checkpoint Inhibitors in Cancer Therapy (2022, background): “Treg cells produce CTLA-4 constitutively because it is a target gene of the forkhead transcription factor FOXP3 [78], whose expression determines the Treg cell lineage [79].”
Development and maintenance of regulatory T cells. (2013, background): “Notably, however, both Foxp3 expression and Treg-cell-type DNA hypomethylation are involved in controlling the expression of some Treg-cell-function-associated molecules, such as Il2ra,Ctla4, and Foxp3 itself, especially upon TCR stimulation (Hill et al., 2007; Hori et al., 2003; Ono et al., 2007).”
Foxp3 in control of the regulatory T cell lineage (2007, methodology): “A recent study used this unique feature of Foxp3 to understand the contribution made by Foxp3 to T reg cell differentiation by inserting the coding sequence of GFP into the Foxp3 locus in a manner allowing concomitant disruption of Foxp3 protein expressio”
The blockade of immune checkpoints in cancer immunotherapy (2012, background): “33 ), the expression of which determines the T Reg cell lineag”
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009, background): “…with contributing a distinct genetic sig- nature to T reg cells, Foxp3 conveys regulatory activity to nT reg cells, iT reg cells, and, upon ectopic expression, in con- ventional T cells (Schubert et al., 2001; Fontenot et al. 2003, 2005; Hori et al., 2003; Gavin et al., 2007; Hill et al., 2007).”
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis (2009, background): “The transferred T reg cell populations expand considerably in vivo , and most maintain Foxp3 expressio”
Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways (2008, background): “FoxP3 is a transcription factor that marks Tregs and also has a critical role for inhibitory function (81, 82).”
The emerging roles of forkhead box (Fox) proteins in cancer (2007, background): “The FoxP family members are crucial for correct immune functioning; FOXP3 regulates the development and function of regulatory B cells, T cells and CD25 + CD4 + regulatory T cells ( T Regs”
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 (2007, result): “However, that idea is strongly supported by the very similar smaller amount of Foxp3 mRNA found after targeted insertion of a GFP-encoding sequence into the Foxp3 locus with concomitant disruption of Foxp3 protein expressio”
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells (2010, neutral): “A number of studies have suggested that Foxp3 is not the major factor that controls the development of the Treg cell lineage (36, 37).”