The mGluR theory of fragile X mental retardation.

By Mark F. Bear, K. Huber, S. Warren. Trends in Neurosciences, 2004

1,566 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f1a6277d6f6fb0c9976091fdc6610e216a6ecf15

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Citations in the corpus

Dendritic mRNA: transport, translation and function (2007, background): “Activation of mGluRs induces an increase in the synthesis of FMRP in the synaptic region, which might in turn limit the response by turning off dendritic synthesi”
Interneuron dysfunction in psychiatric disorders (2012, background): “Inhibitory deficits might be secondary to alterations in glutamatergic transmission, because reducing the levels of metabotropic glutamate receptor 5 (mGluR5) in Fmr1 -null mice rescues many of the neurological phenotypes that are observed in the absence of FMR1 (Re”
Do thin spines learn to be mushroom spines that remember? (2007, background): “Please cite this article in press as: Bourne J, Harris KM, Do thin spines learn to be mushroom spines also display enhancement of LTD mediated by metabotropic glutamate receptors [59].”
Diseases of Unstable Repeat Expansion: Mechanisms and Common Principles (2005, background): “FMRP and its mRNA also localize to DENDRITIC SPINES , where FMRP associates with polyribosomes and is upregulated in response to stimulation by metabotropic glutamate receptors (mGluRs”
Consensus Paper: Pathological Role of the Cerebellum in Autism (2012, background): “The absence of FMRP in mouse knockout models has demonstrated upregulation of mGluR5 and PSD-95 translation [159, 160].”
The autistic neuron: troubled translation? (2008, background): “In the case of FXS, the discovery of enhanced mGluR-dependent LTD suggests that inhibition of mGluR activity may be one way to limit the excessive translational response to mGluR activation (Bear et al., 2004).”
Spatially restricting gene expression by local translation at synapses (2010, neutral): “These findings are consistent with a model whereby in the Fragile X mouse, the protein/s required for mGluR-dependent AMPA receptor internalization and mGluR-LTD are already accumulated at Schaffer collateral to CA1 synapses under basal conditions [85].”
Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb (2011, background): “As Fmrp is involved in the regulation of synaptic plasticity (Bear et al., 2004; Bassell and Warren, 2008), it would be interesting to test the effects of Fmrp loss on a form of plasticity of GCs that we have previously described (Nissant et al.”
Learning rules and persistence of dendritic spines (2010, background): “This question is particularly interesting because both enlargement (or LTP; Tanaka et al., 2008; Yang et al., 2008) and shrinkage of spines (or LTD; Bear et al., 2004; Grossman et al., 2006) are known to depend on protein synthesis, suggesting that new proteins are not simply used to make larger…”
Mutations causing syndromic autism define an axis of synaptic pathophysiology (2011, background): “Indeed, it was exaggerated LTD in the Fmr1 −/y mouse that led to the mGluR theory of FX”
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. (2012, background): “The identification of FMRP and elucidation of its role in translational control have uncovered a critical step downstream from the metabotropic glutamate receptors (Bear et al. 2004).”
De Novo Gene Disruptions in Children on the Autistic Spectrum (2012, background): “GRM5 encodesmGluR5, a glutamate receptor coupled to a G protein (Bear et al., 2004).”