Do thin spines learn to be mushroom spines that remember?

By Jennifer N. Bourne, Kristen M. Harris. Current Opinion in Neurobiology, 2007

856 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/142e323264b45d45f852e6b9e347c09db10c951f

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Structural traces of past experience in the cerebral cortex (2010, positive): “It is an established knowledge that the size of spines strongly correlates with the size and strength of the synapse it carries—the stronger the synaptic connection, the bigger the spine [28], and changes in the transmission strength via synaptic plasticity simultaneously alter spine dimensions [29]”
Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images (2008, background): “Spines come in multiple shapes and sizes, which subserve a diversity of function [2–6].”
Pyramidal neurons: dendritic structure and synaptic integration (2008, background): “It has been suggested that thin, dynamic spines might be available to contribute to learning, whereas larger, more stable spines might be involved in the storage of established memorie”
Spinogenesis and Pruning Scales across Functional Hierarchies (2009, background): “Would this observation also be true for TE and PFC we might conclude that many of these spines simply did not form synapses [for review, see Kasai et al. (2003) and Bourne and Harris (2007)].”
The Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens (2010, background): “Additionally, owing to the transient nature of many electrophysiological changes, we need far more detailed time course information of dendritic plasticity, of LTD/LTP, and of insertion or internalization of glutamate receptors induced by opiates and stimulants that might reflect particular behavior”
COORDINATION OF SIZE AND NUMBER OF EXCITATORY AND INHIBITORY SYNAPSES RESULTS IN A BALANCED STRUCTURAL PLASTICITY ALONG MATURE HIPPOCAMPAL CA1 DENDRITES DURING LTP (2011, methodology): “TBS also elevates intracellular calcium from multiple sources and releases BDNF; events not elicited with tetanic stimulation (Larson et al., 1986; Abraham and Huggett, 1997; Kang et al., 1997;”
Early remodeling of the neocortex upon episodic memory encoding (2014, background): “, mushroom spines) that are more stable and are hypothesized to represent the physical substrates of long-term memories (35).”
Balancing structure and function at hippocampal dendritic spines. (2008, background): “These shaft synapses either reemerge as spines or are preferentially eliminated later in life (Harris 1999, Bourne & Harris 2007).”