Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities.

By H. Zoghbi, Mark F. Bear. Cold Spring Harbor Perspectives in Biology, 2012

770 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/06d007ba6e5caecb403b77aa9dd3e14624b2c0db

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Kevin A. Pelphrey
2. Robert J. Sternberg
3. Rebecca Saxe
4. Jorie Koster-Hale

In Genetics

1. Mark Gerstein

In Molecular Biology

1. Mark Gerstein

Citations in the corpus

• Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits (2014, neutral): “Consistently, increased spine density is observed in frontal, temporal, and parietal lobes in ASD brains (Hutsler and Zhang, 2010) and changes in synaptic structure are detected in multiple Ne ASD model mice (Zoghbi and Bear, 2012).”
• FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders (2015, positive): “Some mutations involve synapse-associated molecules (Sü dhof, 2008; Zoghbi and Bear, 2012) and have led to the widespread notion that alterations in the assembly of synaptic connections are key in the pathophysiology of ASD.”