Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.

By E. Rofstad, B. Mathiesen, Kristil Kindem, Kanthi Galappathi. Cancer Research, 2006

644 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f0ed83d8c870cb57570c906d09952a3ff20b4f2c

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In Biomedical Engineering

In Cancer Research

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Citations in the corpus

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases (2009, background): “This would be consistent with previous observations of Hill and Rofstad, who showed that pretreatment of melanoma cells with acid pH before injection leads to enhanced survival at metastatic sites (10, 11).”
Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007, background): “As discussed earlier, acidic pH induces expression of angiogenic factors [Xu et al., 2002] and thus contributes to growth of metastatic tumors [Rofstad et al., 2006].”
Acidic extracellular microenvironment and cancer (2013, background): “Pretreatment of the tumor cells in an acidic medium induces production of proteinases (MMPs and cathepsins) and proangiogenic factors (VEGF-A and IL-8) and promotes experimental metastasis to the lung after injection into the tail vein of nude mice [5]; elevation of pH by one unit following injectio”
Reactive oxygen species in cancer (2010, background): “an increased formation of lactate and CO2 [202], both favoring extracellular matrix degradation and cell invasion [204].”
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments (2023, background): “Intriguingly, an acid concentration gradient from the center to the outside of the tumor tissue, which naturally forms the metastatic directionality, mediates cell mobility and invasion [290, 291].”
Causes and Consequences of Increased Glucose Metabolism of Cancers (2008, background): “This acid treatment leads to increases in interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and matrix metalloproteinases 2 and 9, and inhibiting these factors reduced both in vitro invasion and in vivo metastasis (218).”
Acidity generated by the tumor microenvironment drives local invasion (2013, background): “Furthermore, cells exposed to in vitro low pH show increased invasion both in vitro and in vivo (9, 13, 14).”
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. (2009, background): “However, acidosis may not always favor metastasis (4, 46).”
Thermo- and pH-responsive polymers in drug delivery. (2006, background): “4 [22] and cancer tissue is also reported to be acidic extracellularly [23,24].”
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. (2007, background): “MMP-2 activity was determined by gelatin zymography.”