Causes and Consequences of Increased Glucose Metabolism of Cancers

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Targeting cellular metabolism to improve cancer therapeutics (2013, background): “yet fully understood, the increased glycolysis observed in cancer cells is well accepted to be important for the support of malignant phenotypes (Box 1).(8)”
Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory (2016, background): “The mutations of oncogenes in the up-regulation of glucose transporters increase the consumption of glucose by cancer cells, increasing the rate of glucose metabolism [41, 42].”
The extracellular matrix modulates the hallmarks of cancer (2014, positive): “Even in the presence of high oxygen tension, tumor cells exploit the anaerobic metabolic process to facilitate rapid cell division [104].”
Regulation of cancer cell metabolism (2011, background): “Adaptation to the resulting acidic microenvironment that is caused by excess lactate production may further drive the evolution of the glycolytic phenotyp”