The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.

By Joke Comijn, G. Berx, P. Vermassen, K. Verschueren, L. V. Grunsven, E. Bruyneel, M. Mareel, Danny Huylebroeck, F. V. Roy. Molecules and Cells, 2001

1,451 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f0c72dfe4465d198afd576afe5b91dc78534fd5e

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In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. J. Massagué
5. Thomas Brabletz
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7. Manel Esteller
8. A. Cano

Citations in the corpus

• Intercellular adhesion, signalling and the cytoskeleton (2002, background): “SIP catalyses a dramatic reduction in E-cadherin gene expression, and correspondingly, a SIP transgene bestowed a marked invasive capacity on transfected MDCK cell”
• Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. (2010, background): “2005), and can be regulated by other transcription factors like dEF1/ZEB1, Sip-1/ZEB2, and E12/ E47 (Grooteclaes and Frisch 2000; Comijn et al. 2001; Perez-Moreno et al. 2001).”
• BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. (2005, background): “SIP1 was shown to be induced by TGF-b, and to downregulate the expression of E-cadherin and induce invasion [48].”
• Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. (2006, background): “a zinc finger–containing protein that binds consensus E-box sequences (38).”
• EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer (2010, background): “Notably, Smads associate with Zeb proteins (Zeb1 and Zeb2/ SIP1) to repress expression of E-cadherin during the initiation of EMT (Verschueren et al., 1999; Comijn et al., 2001; Postigo et al., 2003).”
• TGF-β and epithelial-to-mesenchymal transitions (2005, background): “A role for Slug was also proposed in EMT associated with re-epitelization of cutaneous wounds, while Snail Oncogene was not involved (Savagner et al., 2005), consistent with differential expression of these genes observed in TGFb-induced EMT in keratinocytes, renal tubular epithelial cells, and mamm”
• The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity (2007, background): “, 2002), SIP1 (ZEB2) (Comijn et al., 2001) and E47 (Perez-Moreno et al.”
• The tight junction: a multifunctional complex. (2004, background): “alter TJ protein expression in epithelial tumors (24, 34, 114).”
• Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes (2010, positive): “To do so, we assayed four breast cancer cell lines for expression of the following TFs known to promote EMTs:Gsc (9), FOXC1 (8, 13), FOXC2 (14), Zeb1, Zeb2 (25, 26), Slug (10, 27), Snail (11, 28), and Twist (3), as well as other genes associated with Author contributions: J.H.T., J.I.H., K.K., R.A.W”