Mechanically Activated Integrin Switch Controls α5β1 Function

By J. Friedland, Mark H. Lee, D. Boettiger. Science, 2009

679 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/f0ae4d4c3fcf3678f54f5b25b30db075ca239099

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Atomic and Molecular Physics, and Optics

1. Valerie M. Weaver
2. M. Schwartz
3. B. Hinz
4. Clare M. Waterman
5. A. Engler

In Cell Biology

1. Valerie M. Weaver
2. M. Schwartz
3. B. Hinz
4. A. Horwitz
5. J. Parsons
6. C. Carraher
7. Purva Singh
8. G. Reilly

In Immunology and Allergy

1. Valerie M. Weaver
2. M. Schwartz
3. A. Horwitz
4. C. Carraher
5. Purva Singh
6. J. Parsons
7. B. Hinz
8. A. Mould

Citations in the corpus

• Balancing forces: architectural control of mechanotransduction (2011, neutral): “Proteins within the focal adhesion, including the integrins themselve”
• Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression (2010, background): “Several important molecular players have emerged, including integrins (Paszek et al., 2005; Friedland et al., 2009), focal adhesion proteins such as FAK (Pelham and Wang, 1997; Paszek et al., 2005; Assoian and Klein, 2008), and cytoskeletal tension driven by the action of myosin II (Engler et al.,…”
• Demonstration of catch bonds between an integrin and its ligand (2009, background): “It has recently been proposed that the FN–51 bond can be switched from a relaxed to the tensioned states in response to mechanical force through engaging the synergy site in FN (Friedland et al., 2009).”
• Assembly of Fibronectin Extracellular Matrix (2010, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript (Friedland et al. 2009).”
• Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “In addition, tension on ECM-engaged integrins promotes β1 integrin head binding to synergy sites on fibronectin (Friedland et al. 2009).”
• Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “Also, the presence or absence of specific ECM domains can dramatically influence not only cell adhesion strength (Friedland et al., 2009) but also differentiation (Helen et al., unpublished; Martino et al., 2009; Rowlands et al., 2008; Yasunaga et al., 2005) via conformational changes that enhance…”
• Non-muscle myosin II takes centre stage in cell adhesion and migration (2009, neutral): “The second hypothesis is that NM II-generated force induces conformational changes that expose cryptic binding or activation sites in key adhesion component”
• Cell adhesion: integrating cytoskeletal dynamics and cellular tension (2010, background): “Recently, α5β1 integrin was reported to undergo a conformational change in response to myosin II-generated cytoskeletal force, suggesting that this force, combined with ECM stiffness, triggers an integrin switch that is required to generate signals through the adhesion comple”
• The extracellular matrix at a glance (2010, background): “Indeed, ‘tensed’ FN modulates the catch bond ‘force-activation’ and adhesion assembly of 51-integrin through exposure of its synergy site (Friedland et al., 2009).”
• The myofibroblast: paradigm for a mechanically active cell. (2010, background): “Inhibition of either cell contractile activity or reducing extracellular resistance by growth on soft substrates both suppress the integrin high adhesion switch (Friedland et al., 2009).”
• Integrins in cell migration. (2011, background): “Tension-sensitive molecules include Cas, talin, fibronectin, and integrin (Zhong et al. 1998; Sawada et al. 2006; del Rio et al. 2009; Friedland et al. 2009).”
• Dynamic molecular processes mediate cellular mechanotransduction (2011, neutral): “Other crucial linkages in mechanotransduction, such as fibronectin–integrin (α 5 β 1 integrin”