Non-muscle myosin II takes centre stage in cell adhesion and migration

By M. Vicente-Manzanares, Xuefei Ma, R. Adelstein, A. Horwitz. Nature reviews. Molecular cell biology, 2009

1,966 citations recorded by the source corpus.

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and contractile properties and is regulated by the phosphorylation of its light and heavy chains. The three mammalian NM II isoforms have both overlapping and unique properties. Owing to its position downstream of convergent signalling pathways, NM II is central in the control of cell adhesion, cell migration and tissue architecture. Recent insight into the role of NM II in these processes has been gained from loss-of-function and mutant approaches, methods that quantitatively measure actin and adhesion dynamics and the discovery of NM II mutations that cause monogenic diseases.

Subfields: Cardiology and Cardiovascular Medicine, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/8315d7d918df40d567a252abef79f3a051a03a20

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In Cell Biology

1. M. Schwartz
2. A. Horwitz
3. J. Parsons
4. S. Gupton
5. E. Dent
6. F. Gertler
7. Valerie M. Weaver

In Immunology and Allergy

1. M. Schwartz
2. A. Horwitz
3. J. Parsons
4. S. Gupton
5. Valerie M. Weaver

Citations in the corpus

• The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance (2011, background): “There are three distinct isoforms of nonmuscle myosin II (A, B, and C), and these have overlapping and distinct functions in various aspects of motility and adhesion (Vicente-Manzanares et al. 2009).”
• Cell adhesion: integrating cytoskeletal dynamics and cellular tension (2010, background): “Myosin II also bundles actin filaments owing to its oligomeric nature and actin-binding propertie”