Alternative activation of macrophages

By S. Gordon. Nature reviews. Immunology, 2003

6,493 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/eeb889a7b1c82ab8bcdd22615abefbdddbae8e99

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In Immunology

1. A. Mantovani
2. TA Wynn
3. A. Sica
4. R. Medzhitov
5. S. Gordon
6. R. Locksley
7. P. Allavena
8. Shizuo Akira

Citations in the corpus

• Functional plasticity of macrophages: reversible adaptation to changing microenvironments (2004, background): “The discovery that T cells elaborated cytokines that contributed to macrophage activation and the identification of interferon- (IFN- ) as the cytokine that enhanced macrophage cytotoxicity [8] established the concept that the quality and intensity of macrophage activation depended on the nature of ”
• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “The variety of functional programs adopted by macrophages in response to the stimuli listed above has been termed M2a (IL-4 and IL-13; alternative inflammation), M2b (immune complexes, FcγR/TLR triggering), and M2c (IL-10,TGFβ, glucocorticoids; deactivation) (178, 179).”
• Pathogenetic mechanisms in radiation fibrosis. (2010, background): “As part of an adaptive immune response in chronic inflammatory conditions, fibrogenesis is stimulated by IL-4 and IL-13 produced by the Thy-2 subset of CD4+ T lymphocytes [22,40].”
• Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. (2008, background): “Adipocytes Are a Source of Th2 Cytokines Macrophage alternative activation is mainly induced by IL-13 and IL-4, both of which activate STAT6 for signal transduction (Gordon, 2003).”
• Para-inflammation in the aging retina. (2009, background): “, 2007), suggesting an alternatively activated macrophage phenotype (M2 macrophages) (Gordon, 2003).”
• Adipocytokines in Obesity and Metabolic Disease (2014, neutral): “M2 macro- phages produce IL10 and IL1 receptor antagonists and arginase-1 and have been implicated in tissue remodeling (Gordon 2003).”
• Macrophage Polarization in Bacterial Infections (2008, background): “Macrophages are dynamic and heterogeneous cells; this is due to different mechanisms governing their differentiation, tissue distribution, and responsiveness to stimuli (4, 5).”
• M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide (2015, background): “They also produce high levels of reactive oxygen and nitrogen species [4].”
• Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature (2012, background): “from powerful stimulation of inflammatory responses to induction of immunosuppression [66].”
• Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression1 (2006, background): “The various forms of M2 macrophages share an IL-12 and IL-23 phenotype, generally display high levels of scavenger, mannose (13), and galactose-type receptors (3), and arginine metabolism is shifted to production of ornithine and polyamines via arginase (14).”