Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

By Kihwa Kang, Shannon M. Reilly, Matthew R. Gangl, Kelly M. Fitzgerald, B. Hatano, Chih‐Hao Lee. Cell Metabolism, 2008

717 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4f160337079bb3b44f92e54872f76da3bf8bc028

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Citations in the corpus

Regulation of learning and memory by meningeal immunity: a key role for IL-4 (2010, background): “This striking Th2 skewing of the T cell phenotype pointed to a potential alternative (M2) mode of activation of meningeal myeloid cells by these T cells (Kang et al., 2008; Martinez et al., 2008; Odegaard et al., 2008).”
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages (2013, background): “Adipocytes are also re ported to be potential sources of IL4 and IL13 (Kang et al., 2008), but we have not observed fluorescence in adipocytes using IL4 or IL13 cytokine marker alleles (Wu et al., 2011; Fig.”
Krüppel-like factor 4 regulates macrophage polarization. (2011, background): “Consistent with the view that ATMs in obese subjects assume an M1 phenotype, a significant reduction in KLF4 expression was seen in adipose tissue from obese human subjects.”
Macrophage plasticity and polarization: in vivo veritas. (2012, neutral): “Mice with macrophage-selective genetic inactivation of PPAR γ , PPAR δ , and KLF4 show inhibition of obesity-induced insulin resistance (19, 20, 24, 106, 110), although these results may be strain specific (112).”
Macrophage activation and its role in repair and pathology after spinal cord injury. (2015, background): “Particularly, PPAR activation in macrophages causes the induction of M2 markers including Arg1, CD206, Ym1 and FIZZ1 and the effect is lost in PPAR deficient mice (Bouhlel et al., 2007; Odegaard et al., 2007, 2008; Gallardo-Soler et al., 2008; Kang et al., 2008).”
Mitochondria in the regulation of innate and adaptive immunity (2015, neutral): “Furthermore, the loss of the transcription factors of the peroxisome proliferator-activated receptor (PPAR) family, transcription factors known to activate oxidative metabolism in numerous tissues, leads to a deficit in M2 polarization (Kang et al., 2008; Odegaard et al., 2007, 2008).”
Transcriptional control of mitochondrial biogenesis and function. (2009, background): “PGC-1β, which is important for macrophage alternative activation (62), is expressed at reduced levels in PPARδ null macrophages (63).”
Macrophages, immunity, and metabolic disease. (2014, background): “, 2007) and PPARd (Desvergne, 2008; Kang et al., 2008; Odegaard et al., 2008), which are critical for the mainte-”