Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

By F. Heil, H. Hemmi, H. Hochrein, Franziska Ampenberger, C. Kirschning, Shizuo Akira, G. Lipford, H. Wagner, S. Bauer. Science, 2004

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In vivo delivery of miRNAs for cancer therapy: Challenges and strategies (2014, background): “The GU-rich sequence of let-7b displays a binding motif interacting with TLR 7 [80].”
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction (2005, background): “TLR7, the TLR9 subfamily member that is activated by single-stranded (ss)RN”
siRNAs: applications in functional genomics and potential as therapeutics (2004, background): “Recent data have demonstrated that humans and mice express TLRs that are activated by uridine/guanosine- and uridine-rich single-stranded RNA oligonucleotides, respectivel”
Plasmacytoid dendritic cells in immunity (2004, neutral): “This has been demonstrated with single-stranded RNA (ssRNA) viruses such as influenz”
Sex-based differences in susceptibility to SARS-CoV infection (2017, background): “Moreover, high viral RNA levels in the lungs of male mice may stimulate TLR7 on IMMs, resulting in elevated proinflammatory cytokines and chemokines (48).”