Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

By K. Honda, Y. Ohba, H. Yanai, Hideo Negishi, T. Mizutani, A. Takaoka, C. Taya, Tadatsugu Taniguchi. Nature, 2005

963 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fda3210e7a4bb829650477bff60732a68d3feb77

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In Immunology

Citations in the corpus

Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “The latter is likely, as DCs in DC-MyD88 ⁄ ) mice injected with CpGDOTAP still fail to produce IL-12 and as encapsulation of CpG in DOTAP is known to increase the range of cells and responses to the TLR9 agonist (50).”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “However, TLR9-mediated IRF7 activation occurs early in the endosomal pathway, and TLR9 signaling in macrophages proceeds normally when the sorting adaptor TIRAP is restricted to early endosomes (81, 169).”
Toll-like receptors in antiviral innate immunity (2013, background): “TLR9 can also be stimulated by three different classes of synthetic CpG oligodeoxynucleotides (ODNs)mediating type I IFNproduction andBcell activation [135,136].”
Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand (2007, background): “Total RNA was immediately isolated with the RNeasy kit (QIAGEN) and used to generate cDNA according to the Expression Analysis Technical Manual from Aff ymetrix, Inc. Complementary RNA samples were generated with the BioArray HighYield RNA Transcript Labeling kit (Enzo Life Sciences) and the human g”
Pathogen recognition and innate immunity. (2006, positive): “Among nine IRF family members, IRF-3 and IRF-7 are essential for the induction of type I IFN production since virus-mediated IFN production is severely impaired in IRF-7 / mice and was abrogated in IRF-3 / IRF-7 / cells (Honda et al., 2005b).”
Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “TLR9 signaling by IFN-inducing large multimeric (type A) CpG oligonucleotides occurs in early endosomes, whereas monomeric (type B) CpG are transferred to endolysosomes and fail to induce IFN (74, 76).”
Endocytosis and signalling: intertwining molecular networks (2009, positive): “Indeed, in plasmacytoid dendritic cells ligand-activated TLR9 directly interacts with MYD88 and the transcription factor IRF7, and these complexes are retained for a long time in endosomes and escape lysosomal degradatio”