Mechanisms of bone metastasis.

By G. Roodman. Discover medicine, 2004

2,563 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/ed88572c24427efbf2976cb7d4ace5466aac6d4b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. O. De Wever
2. M. Mareel
3. D. Garfield
4. R. Langley
5. A. F. Stewart
6. E. Eriksen
7. Qi Jiang
8. Jianhua Wang

In Oncology

1. R. Langley
2. M. Mareel
3. O. De Wever
4. D. Garfield
5. A. F. Stewart
6. E. Eriksen
7. Qi Jiang
8. Jianhua Wang

In Radiology, Nuclear Medicine and Imaging

1. M. Mareel
2. D. Garfield
3. R. Langley
4. A. F. Stewart
5. E. Eriksen
6. Jianhua Wang
7. E. Keller
8. Y. Mao

Citations in the corpus

• Cellular mechanisms of bone remodeling (2010, background): “The local effects of TGFβ in the bone microenvironment are two-fold: 1) it enhances the growth of bone metastases and 2) increases PTHrp formation from tumor cells further [62], thus maintaining the vicious cycle.”
• Immune evasion in cancer: Mechanistic basis and therapeutic strategies. (2015, positive): “Among other factors, once again, it is the TGFecreted by the cancer cells that makes a major contribution to umor metastasis [89].”
• Stroma Cells in Tumor Microenvironment and Breast Cancer (2012, positive): “Interestingly, when breast cancer cells homed to the bone marrow through CXCL12/CXCR4 interaction caused by stem cells and circulating leukocytes [52], osteoclastic activation was induced by parathyroid hormone-related protein (PTHrP) and other soluble mediators released from the metastatic cells [5”
• Hypercalcemia Associated with Cancer (2005, background): “Direct comparison of sustained infusion of human parathyroid hormone-related protein(1-36) [hPTHrP-(1-36)] versus hPTH-(1-34) on serum calcium, plasma 1,25-dihydroxyvitamin D concentrations, and fractional calcium excretion in healthy human volunteers.”
• Cancer to bone: a fatal attraction (2011, neutral): “Devastating consequences of bone metastases include pathological bone fractures, pain, hypercalcaemia, and spinal cord and nerve-compression syndrome”
• Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. (2011, background): “Denosumab has been studied in two phase II trials of patients with bone metastasis and advanced cancer and in one phase II trial with myeloma.26-28 These studies showed that treatment with denosumab at doses ranging from 30 to 180 mg administered every 4 or 12 weeks was associated with rapid and sus”
• American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer (2012, positive): “The mechanisms of bone metastases occurring and propagating are complex but may be similar in different diseases (211,212).”
• Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. (2011, background): “Introduction Metastases represent the most common malignant tumors involving the skeleton: nearly 70% of patients with breast cancer or prostate cancer (PCa) — and approximately 15%–30% of patients with carcinomas of the lung, colon, stomach, bladder, uterus, rectum, thyroid, or kidney — have bone l”
• Bone imaging in metastatic breast cancer. (2004, background): “However, because all types of bone metastases show constant activation of osteoclasts, bisphosphonates and other osteoclast inhibitors are effective against all types of bone metastases.(32) Breast cancer preferentially metastasizes to vertebrae and the pelvis, followed by ribs, skull, and femur,(1,”
• Alpha emitter radium-223 and survival in metastatic prostate cancer. (2013, neutral): “Diarrhea 151 (25) 9 (2) 0 0 45 (15) 5 (2) 0 0”
• Treating metastatic cancer with nanotechnology (2011, background): “Bone metastases, which often occur in high multiplicity, can result in bone degradation and complications such as fractures, hypercalcaemia and nerve compressio”
• The seed and soil hypothesis revisited - the role of tumor-stroma interactions in metastasis to different organs (2011, background): “positive feedback loop by signaling for increased production of PTHrP from tumor cells.(32) The proangiogenic and immunosuppressive properties of TGF-b may also contribute to”
• Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. (2010, background): “Osteoclasts resorb bone, thereby releasing growth factors that may promote tumor cell proliferation, metastasis, and survival, thus perpetuating a vicious cycle of tumor expansion and bone resorption.(18) Denosumab is a fully human monoclonal antibody that specifically binds human RANKL to inhibit o”
• Role of tissue stroma in cancer cell invasion (2003, background): “A paradigm of successful treatment targeted at host cells is provided by the use of bisphosphonates in bone metastasis [260].”