Treating metastatic cancer with nanotechnology

By Avi Schroeder, D. Heller, M. Winslow, J. Dahlman, George W. Pratt, R. Langer, T. Jacks, Daniel Anderson. Nature Reviews. Cancer, 2011

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Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe (2014, background): “The emergence of such probes, which have been tailored and refined to address metastatic disease detection (3) and other key issues, including targeted drug delivery (4), pharmacokinetics (PK) (5), and immune response to tumors (6), has led to promising technological advances defining the forefront ”
Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics (2016, background): “Cancer metastasis is one of the greatest challenges in cancer therapy, which is responsive for over 90% of cancer-related deaths of many types of cancers [1-3].”
Nanoparticles for Cancer Therapy: Current Progress and Challenges (2021, background): “This is also used to treat nodal metastases in prostate and testicular cancer and was approved by FDA in June 2009 [106, 107].”
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “Since primary and metastatic lesions may exhibit different behavior [113, 114], it is still not clear if the deposition of NPs in metastases correlates to that of primary tumors [125].”