The seed and soil hypothesis revisited - the role of tumor-stroma interactions in metastasis to different organs

By R. Langley, I. J. Fidler. International Journal of Cancer, 2011

907 citations recorded by the source corpus.

The fact that certain tumors exhibit a predilection for metastasis to specific organs has been recognized for well over a century now. An extensive body of clinical data and experimental research has confirmed Stephen Paget's original “seed and soil” hypothesis that proposed the organ‐preference patterns of tumor metastasis are the product of favorable interactions between metastatic tumor cells (the “seed”) and their organ microenvironment (the “soil”). Indeed, many of the first‐line therapeutic regimens, currently in use for the treatment of human cancer are designed to target cancer cells (such as chemotherapy) and also to modulate the tumor microenvironment (such as antiangiogenic therapy). While some types of tumors are capable of forming metastases in virtually every organ in the body, the most frequent target organs of metastasis are bone, brain, liver and the lung. In this review, we discuss how tumor‐stromal interactions influence metastasis in each of these organs.

Subfields: Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/96f26f8864d2833e830aaddf444280d3e61b60cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. Sang Hun Lee
2. Anant Madabhushi
3. Y. Fouad
4. P. Chiarugi
5. C. Yun
6. C. Aanei

In Pulmonary and Respiratory Medicine

1. Y. Fouad
2. P. Chiarugi
3. C. Aanei

Citations in the corpus

• Revisiting the hallmarks of cancer. (2017, positive): “In conclusion, our current understanding would suggest that both the “seed and soil” and the “anatomical-mechanical” hypotheses are not mutually exclusive and reflect two mechanisms that serve together in a contextdependent manner to varying degrees [102, 130].”
• Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, background): “Glutamine Metabolism and Tumor Microenvironment Glutamine metabolism is also profoundly influenced by the extracellular tumor microenvironment (52).”
• Predicting cancer outcomes with radiomics and artificial intelligence in radiology (2021, background): “This finding suggests that heterogeneity measures of healthy organ tissue beyond the site of primary disease might be reflective of biology that might provide a more viable premetastatic niche for invasive tumours 110 .”
• Anoikis molecular pathways and its role in cancer progression. (2013, background): “of the invading cells in the new site [137,151].”
• The Roles of Autophagy in Cancer (2018, background): “In primary cancer cells, autophagy is induced by hypoxia and nutrient deprivation and protects against cell necrosis and inflammation [100,101,102].”