Cancer to bone: a fatal attraction
By K. Weilbaecher, T. Guise, L. McCauley. Nature Reviews. Cancer, 2011
1,223 citations recorded by the source corpus.
When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the bone microenvironment to enhance tumour growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumour–bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.
View Paper: https://www.semanticscholar.org/paper/8e19bc2cee9226cffa317f152c29d27c35df841d
Citations in the corpus
- The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, neutral): “These factors stimulate cancer cells in a feed-forward cycle of tissue destruction and metastatic expansion (Ell and Kang, 2012; Weilbaecher et al., 2011).”
- EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript differentiation (Weilbaecher et al., 2011).”