Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity
By Yong-Xu Wang, Chih-Hao Lee, Sambath Tiep, R. Yu, J. Ham, Heonjoong Kang, Ronald M. Evans. Cell, 2003
1,251 citations recorded by the source corpus.
Subfields: Biochemistry, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/ed08f7a6b896187279d6e73eb5cd124ad9d997a3
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In Biochemistry
- B. Spiegelman
- Christoph Handschin
- Jianping Ye
- Christopher K. Glass
- Jiandie D. Lin
- D. Hardie
- Haiming Cao
In Molecular Biology
- B. Spiegelman
- Christoph Handschin
- Johan Auwerx
- Jiandie D. Lin
- D. Kelly
- B. Finck
- Mitchell A. Lazar
- L. Michalik
In Physiology
- B. Spiegelman
- Johan Auwerx
- Christoph Handschin
- Jiandie D. Lin
- C. Cantó
- D. Kelly
- B. Finck
- Jianping Ye
Citations in the corpus
- Regulation of Muscle Fiber Type and Running Endurance by PPARδ (2004, methodology): “Total muscle protein extracts (Lin et al. 2002) and nuclear proteins (Wang et al. 2003) were prepared as described.”
- Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008, background): “In addition, activation of PGC-1a signaling most likely synergizes with increased PPAR expression, as PGC-1a is a coactivator of PPARa- and PPARb/d-mediated FAO (Vega et al., 2000; Wang et al., 2003).”
- Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. (2008, background): “PPARd has been shown to transcriptionally regulate oxidative metabolism in muscle and improve insulin sensitivity (Lee et al., 2006b; Schuler Cell Metabolism 7, 485–495, June 2008 ª2008 Elsevier Inc. 485 et al., 2006; Tanaka et al., 2003; Wang et al., 2003).”
- PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. (2006, background): “PPARβ (21), thyroid hormone receptor (1), retinoid receptors (1), glucocorticoid receptor (22), estrogen receptor (1, 22, 23), farnesyl X receptor (FXR) (24), pregnane X receptor (PXR) (25), hepatic nuclear factor-4 (HNF-4) (26), liver X receptor (LXR) (27), and the estrogen-related receptors (ERRs)”
- International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006, background): “In animal models, PPAR / agonists retard weight increase under high-fat diet conditions and therefore maintain insulin sensitivity probably by stimulating skeletal muscle fatty acid metabolism and thermogenesis (Wang et al., 2003).”
- Metabolic control through the PGC-1 family of transcription coactivators. (2005, background): “…Wu et al., 1999 NRF-2 + ND mitochondrial genes Mootha et al., 2003 PPARα + + fatty-acid oxidation Vega et al., 2000 PPARβ/δ + ND fatty-acid oxidation Wang et al., 2003 PPARγ + + UCP1/GyK induction Guan et al., 2005; Puigserver et al., 1998 Huss et al., 2002; Huss et al., 2004; Kamei et al.,…”