Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells.

By S. Nilsson, Hayley M. Johnston, G. Whitty, B. Williams, Ryan J. Webb, D. Denhardt, I. Bertoncello, L. Bendall, P. Simmons, D. Haylock. Blood, 2005

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Arteriolar niches maintain haematopoietic stem cell quiescence (2013, positive): “N-cadherin + osteoblasts have been proposed to promote HSC quiescence via direct contact 12,14 and secretion of angiopoietin-1 15 or osteopontin 16,17 .”
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche (2007, background): “For example, ECM proteins, such as tenascin C, osteopontin and the combination of Bgn and decorin, have been found to control the number of neural stem cells, hematopoietic stem cells and BMSCs, respectivel”
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells (2006, background): “The bone-related protein osteopontin is involved in regulation of stem cell migration, homing, anchorage, proliferation and quiescence in the endosteum regio”
The stem-cell niche as an entity of action (2006, background): “Third, another matrix protein, the Arg–Gly–Asp (RGD)-containing sialoprotein, osteopontin (OPN), has now been demonstrated to contribute to HS-cell regulatio”